{"id":"W2977288533","doi":"10.1152/ajprenal.00195.2019","title":"Forward genetic screen in human podocytes identifies diphthamide biosynthesis genes as regulators of adhesion","year":2019,"lang":"en","type":"article","venue":"American Journal of Physiology-Renal Physiology","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Eye Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Medical Research Council; Canadian Institutes of Health Research; Terry Fox Foundation; Kidney Research UK","keywords":"Podocyte; Cell biology; Biology; Adhesion; Fibronectin; Cell adhesion; Gene knockdown; Gene; Genetic screen; Genetics; Phenotype; Chemistry; Extracellular matrix; Kidney","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002464675,0.0005061139,0.0004869305,0.0004055166,0.0002512069,0.0003511551,0.0003108612,0.0003606258,0.001717592],"category_scores_gemma":[0.0001531715,0.0002426947,0.0005125424,0.0003448502,0.0001808916,0.00008390238,0.0003234683,0.0005113814,0.0005933066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000293245,"about_ca_system_score_gemma":0.0003353971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171418,"about_ca_topic_score_gemma":0.002372764,"domain_scores_codex":[0.9997421,0.0000246336,0.00002297151,0.00006499714,0.0001158424,0.00002941706],"domain_scores_gemma":[0.9998617,0.00004437899,0.00003442272,0.00001864462,0.00001483167,0.00002607121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002575794,0.00001482882,0.0002362173,0.00002305481,0.00000664221,0.00007192987,0.000004512468,0.00004993487,0.998481,0.00002974993,0.00005846904,0.0009979738],"study_design_scores_gemma":[0.0000366383,0.0002443565,0.008556002,0.000006772344,0.00006780373,0.0005437913,0.00001735248,0.001313576,0.9852375,0.00004035709,0.003924859,0.00001095802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573419,0.002267048,0.02783765,0.000346871,0.00006797885,0.0003551658,0.008096833,0.001057343,0.002629202],"genre_scores_gemma":[0.956498,0.002533447,0.02732669,0.000282087,0.00001456158,0.0003021722,0.007005828,0.000142295,0.005894844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001717592,"threshold_uncertainty_score":0.005745947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007306820863843697,"score_gpt":0.2639757386027408,"score_spread":0.2566689177388971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}