{"id":"W2977310905","doi":"10.1093/annonc/mdz263.011","title":"Comparison between phase III randomized clinical trials and their preceeding phase II studies","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Hazard ratio; Phases of clinical research; Adverse effect; Clinical trial; Cancer; Randomized controlled trial; Oncology; Surgery; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1004249,0.002648741,0.009954204,0.0024625,0.0007559457,0.003839353,0.002312493,0.003715153,0.01170198],"category_scores_gemma":[0.1858092,0.001152086,0.01340017,0.002334964,0.002110125,0.004411743,0.00196093,0.004820064,0.0009639987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002468379,"about_ca_system_score_gemma":0.002349203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005994047,"about_ca_topic_score_gemma":0.0009783556,"domain_scores_codex":[0.8310071,0.1442486,0.01330236,0.004610202,0.005365742,0.001466024],"domain_scores_gemma":[0.6973155,0.2582689,0.02370201,0.01046496,0.006848645,0.003399951],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8887374,0.0007835389,0.002018305,0.009726655,0.05267072,0.00006270796,0.0001599805,0.001135521,0.0009021906,0.001517326,0.001802942,0.04048267],"study_design_scores_gemma":[0.7786117,0.1169714,0.01358294,0.00351094,0.06152082,0.0001868966,0.0002238091,0.003154308,0.001261753,0.007504581,0.01329838,0.0001724666],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.452574,0.344438,0.07133562,0.005697937,0.01939174,0.06518368,0.01529542,0.001151475,0.02493199],"genre_scores_gemma":[0.8915211,0.02231007,0.03148073,0.005983074,0.002902455,0.03513583,0.005599368,0.0003492034,0.004718212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8995751,"threshold_uncertainty_score":0.5311039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4934887322883962,"score_gpt":0.6171006475427235,"score_spread":0.1236119152543273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}