{"id":"W2977350079","doi":"10.1111/exd.14043","title":"Increased expression of TLR7 and TLR9 in alopecia areata","year":2019,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Canadian Dermatology Foundation; National Alopecia Areata Foundation","keywords":"TLR9; Alopecia areata; TLR7; Peripheral blood mononuclear cell; Pathogenesis; Hair follicle; Hair loss; Autoimmune disease; Innate immune system; Immune system; Immunology; Downregulation and upregulation; Receptor; Medicine; Biology; Endocrinology; Internal medicine; Toll-like receptor; Gene expression; Antibody; Dermatology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000140608,0.0001491444,0.0001480789,0.0005735237,0.0001958855,0.0002270622,0.00006535536,0.0003080081,0.001983118],"category_scores_gemma":[0.0002591494,0.0001036608,0.0001861253,0.0001801202,0.0001768276,0.0001206177,0.0001496368,0.0002311181,0.0002828497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008773754,"about_ca_system_score_gemma":0.00004728237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000165574,"about_ca_topic_score_gemma":0.0001808156,"domain_scores_codex":[0.9998688,0.00003142826,0.00001159844,0.00003175502,0.00002884679,0.0000276407],"domain_scores_gemma":[0.9998114,0.00005065656,0.00006381441,0.00001241106,0.00003216619,0.00002965872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001284019,0.0001127369,0.08815567,0.0001908014,0.00006395395,0.002227584,0.0002031925,0.00007139063,0.896605,0.00006487329,0.0001577408,0.0108631],"study_design_scores_gemma":[0.00008817658,0.001217069,0.919722,0.00003164322,0.0001033278,0.01565506,0.0004966366,0.0006480521,0.06017304,0.0002450576,0.001603939,0.00001600467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984212,0.0007968229,0.0001885686,0.00002050968,0.000007912021,0.000005743056,0.00008551194,0.00000972874,0.0004641156],"genre_scores_gemma":[0.9993083,0.0001608023,0.0001816275,0.00002374778,0.0000101681,0.000005356637,0.00006872108,0.000001751039,0.0002393898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001983118,"threshold_uncertainty_score":0.006634176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006699514219190322,"score_gpt":0.2633201779468515,"score_spread":0.2566206637276611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}