{"id":"W2977350079","doi":"10.1111/exd.14043","title":"Increased expression of TLR7 and TLR9 in alopecia areata","year":2019,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Hair Growth and Disorders","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Canadian Dermatology Foundation; National Alopecia Areata Foundation","keywords":"TLR9; Alopecia areata; TLR7; Peripheral blood mononuclear cell; Pathogenesis; Hair follicle; Hair loss; Autoimmune disease; Innate immune system; Immune system; Immunology; Downregulation and upregulation; Receptor; Medicine; Biology; Endocrinology; Internal medicine; Toll-like receptor; Gene expression; Antibody; Dermatology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002549369,0.00009064356,0.0002834098,0.0001074095,0.00001163146,0.000002188316,0.00004327042,0.00008379444,0.0003799504],"category_scores_gemma":[0.00001671948,0.00007933849,0.00002704979,0.00006993937,0.0000723956,0.00005663911,0.00005629415,0.00006764191,0.00004674822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001494391,"about_ca_system_score_gemma":0.00002852676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001082708,"about_ca_topic_score_gemma":0.000008559167,"domain_scores_codex":[0.9993671,0.00003783991,0.0001893678,0.0001691161,0.00008182801,0.0001547824],"domain_scores_gemma":[0.9996821,0.00003175433,0.00003316284,0.0001610615,0.000009478823,0.00008241631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003114883,0.0002276111,0.524444,0.00006131722,0.000006049335,0.00007051066,0.0008308197,1.771649e-7,0.4729363,0.0003476712,0.0006367711,0.0001272862],"study_design_scores_gemma":[0.00461573,0.0001506228,0.08630851,0.00008447871,0.000005192291,0.0003574378,0.002404094,0.00007197353,0.9043188,0.00004545102,0.001538071,0.00009962612],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847594,0.001915727,0.000004787444,0.0001458765,0.00005963679,0.0002457986,0.000002309283,0.00001537315,0.01285108],"genre_scores_gemma":[0.9992877,0.00001921695,0.0002195082,0.0003638876,0.000007621787,0.00001280942,0.00002496963,0.00000938972,0.00005486358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4381355,"threshold_uncertainty_score":0.4160191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006699514219190322,"score_gpt":0.2633201779468515,"score_spread":0.2566206637276611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}