{"id":"W2977390077","doi":"10.1093/ije/dyz193","title":"Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium","year":2019,"lang":"en","type":"article","venue":"International Journal of Epidemiology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Niilo Helanderin Säätiö; Medical Research and Materiel Command; National Heart, Lung, and Blood Institute; Servicio Gallego de Salud; Programme Grants for Applied Research; Instituto de Salud Carlos III; Cancer Council Tasmania; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; National Institute of Environmental Health Sciences; U.S. Army; National Institutes of Health; Hellenic Health Foundation; Xunta de Galicia; Institut Gustave-Roussy; Centers for Disease Control and Prevention; Institut National Du Cancer; Deutsche Krebshilfe; Swedish Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Vetenskapsrådet; University of Cambridge; Government of Canada; Ministerio de Sanidad, Servicios Sociales e Igualdad; Health and Medical Research Fund; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Institut National de la Santé et de la Recherche Médicale; Cancer Australia; Agence Nationale de la Recherche; National Institute on Aging; Robert Bosch Stiftung; Agency for Science, Technology and Research; Cancer Council South Australia; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; Fondation de France; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Lon V. Smith Foundation; Fondation du cancer du sein du Québec; National Breast Cancer Foundation; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; David F. and Margaret T. Grohne Family Foundation; Cancer Research UK; Hamburger Krebsgesellschaft; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; VicHealth; Cancer Council Victoria; California Department of Public Health; U.S. Department of Health and Human Services; Cancer Council Western Australia; European Commission; Breast Cancer Research Foundation; Stavros Niarchos Foundation; Cancer Council NSW; Susan G. Komen for the Cure; KWF Kankerbestrijding","keywords":"Breast cancer; Odds ratio; Oncology; Medicine; SNP; Cancer; Single-nucleotide polymorphism; Internal medicine; Logistic regression; Estrogen receptor; Case-control study; Genotype; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01746902,0.001027902,0.001639838,0.00204367,0.001043081,0.001449057,0.001256811,0.0007954835,0.001742819],"category_scores_gemma":[0.0202269,0.0006911185,0.003979706,0.004481351,0.0007129748,0.0004429405,0.00160843,0.001006316,0.0001570365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007126341,"about_ca_system_score_gemma":0.001651603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01174901,"about_ca_topic_score_gemma":0.01743482,"domain_scores_codex":[0.9840687,0.009318035,0.001224999,0.003062212,0.001626103,0.0006999709],"domain_scores_gemma":[0.9783304,0.01319422,0.003961673,0.002998295,0.0008827943,0.0006326609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002669325,0.00007620525,0.9581335,0.0003118913,0.02646734,0.0004668863,0.0002009735,0.001456187,0.002234747,0.0001333118,0.0003089369,0.007540565],"study_design_scores_gemma":[0.0003360517,0.0007140323,0.9714605,0.00005656398,0.02157132,0.0008111612,0.0001457684,0.002130098,0.001213297,0.0003852598,0.001128005,0.00004793591],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988786,0.003390622,0.004936443,0.0001578265,0.00001971218,0.00007774484,0.00203628,0.00007664602,0.0005187161],"genre_scores_gemma":[0.9949089,0.0003681959,0.003186138,0.0000443886,0.00001852494,0.0001241878,0.00117799,0.00002270727,0.0001490959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01746902,"threshold_uncertainty_score":0.09238613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020190116483429,"score_gpt":0.367032032303804,"score_spread":0.3468301311389698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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