{"id":"W2977398957","doi":"10.1093/annonc/mdz246.092","title":"Phase II trial of trametinib (T) and panitumumab (Pmab) in RAS/RAF wild type (wt) metastatic colorectal cancer (mCRC)","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Panitumumab; Medicine; Trametinib; Colorectal cancer; Oncology; Internal medicine; Cancer research; Cancer; KRAS; MAPK/ERK pathway; Kinase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009008444,0.001340797,0.001758825,0.0003894875,0.0004127765,0.0011697,0.0007765578,0.001334714,0.0054155],"category_scores_gemma":[0.0006428984,0.0006818505,0.001406624,0.0003957302,0.0008136437,0.00106237,0.0003301077,0.003466036,0.001344244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001176517,"about_ca_system_score_gemma":0.001415225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002198935,"about_ca_topic_score_gemma":0.005967469,"domain_scores_codex":[0.9997755,0.00007350924,0.00001042715,0.00005071942,0.00001752218,0.00007246808],"domain_scores_gemma":[0.9995005,0.00005968198,0.00007144114,0.00003642793,0.00002417804,0.0003076746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8748556,0.02105442,0.002551304,0.0006598539,0.001252861,0.0001950376,0.0001832469,0.002597652,0.02345954,0.0003993365,0.0054578,0.06733337],"study_design_scores_gemma":[0.7179007,0.2624492,0.009666168,0.00004461595,0.0005547381,0.0003706131,0.00009981083,0.002015019,0.002732498,0.0003118873,0.003811403,0.00004337418],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905523,0.002792175,0.0003419434,0.0008111175,0.000314149,0.001046001,0.00125194,0.0001292791,0.002761122],"genre_scores_gemma":[0.9863579,0.002359224,0.001071148,0.000877532,0.0001756533,0.001282186,0.002618464,0.00004382073,0.00521394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0054155,"threshold_uncertainty_score":0.01811665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09370440168895344,"score_gpt":0.4336638478199584,"score_spread":0.3399594461310049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}