{"id":"W2977543492","doi":"10.1172/jci128475","title":"Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Deutschen Multiple Sklerose Gesellschaft; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Multiple sclerosis; Immune system; Immunology; Monozygotic twin; Medicine; Acquired immune system; Biology; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001854931,0.0002985283,0.0002424288,0.0009807625,0.0004615115,0.0003120715,0.0001631236,0.00035739,0.001464013],"category_scores_gemma":[0.001477759,0.0002398645,0.000169679,0.0003673356,0.0002519363,0.00009905302,0.0003178829,0.00030566,0.0001688874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001825033,"about_ca_system_score_gemma":0.0001263833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511651,"about_ca_topic_score_gemma":0.001533778,"domain_scores_codex":[0.9996897,0.00006852161,0.00003502132,0.00008774736,0.00007787654,0.00004118936],"domain_scores_gemma":[0.9995713,0.00008556334,0.0001430998,0.00004378813,0.00005991786,0.00009633365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002436995,0.0001772317,0.772127,0.00007009294,0.0001350188,0.008449656,0.002009212,0.00009742909,0.2069394,0.0002450902,0.0002394625,0.007073342],"study_design_scores_gemma":[0.00002362623,0.0003907418,0.9683548,0.00001308812,0.00007025104,0.01930243,0.0004558247,0.0002388669,0.01057639,0.00009030879,0.00047457,0.000008980032],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996804,0.00005480026,0.00006345312,0.000006969079,0.000003195138,0.000004076111,0.00002579215,0.000001672537,0.0001595916],"genre_scores_gemma":[0.9994997,0.00004538128,0.0001683953,0.00001441509,0.000004207243,0.000005785561,0.00007370009,0.000003408312,0.0001850358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001511651,"threshold_uncertainty_score":0.004897594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1745867022190982,"score_gpt":0.3625801731286031,"score_spread":0.187993470909505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}