{"id":"W2977543492","doi":"10.1172/jci128475","title":"Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Deutschen Multiple Sklerose Gesellschaft; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research","keywords":"Multiple sclerosis; Immune system; Immunology; Monozygotic twin; Medicine; Acquired immune system; Biology; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001758966,0.0001618237,0.0007190737,0.0003005872,0.00004405552,0.00002889064,0.0001262991,0.0001600662,0.00002805151],"category_scores_gemma":[0.004774387,0.000114223,0.0001543952,0.0005622867,0.000230214,0.0005290518,0.00004469314,0.0009651337,0.00002592036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001479309,"about_ca_system_score_gemma":0.0004448533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000148698,"about_ca_topic_score_gemma":0.00004665153,"domain_scores_codex":[0.9969041,0.0003435287,0.001481808,0.0002393214,0.0007769786,0.0002543121],"domain_scores_gemma":[0.9965317,0.001178019,0.0009601568,0.0002331462,0.0008398298,0.0002571284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003218617,0.0002978116,0.8870407,0.00005420695,0.0001811697,0.00001105419,0.0005479128,0.0002739129,0.1020363,0.00001418462,0.00004521517,0.006278872],"study_design_scores_gemma":[0.007592091,0.003729706,0.9670597,0.001448245,0.0000511489,0.00001033092,0.0002567623,0.006089049,0.01357057,0.00006033635,0.00001968238,0.0001124192],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975432,0.00004362271,0.0002791949,0.001076445,0.000139059,0.0007864267,0.000001775587,0.00001778582,0.000112485],"genre_scores_gemma":[0.9932314,0.00008115372,0.006209506,0.0001229061,0.0002409185,0.00001333914,0.000004293413,0.00002396917,0.00007247621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08846575,"threshold_uncertainty_score":0.5715732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1745867022190982,"score_gpt":0.3625801731286031,"score_spread":0.187993470909505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}