{"id":"W2977680118","doi":"10.1093/annonc/mdz253.023","title":"A phase I study of Sym021, an anti-PD-1 antibody (Ab), alone and in combination with Sym022 (anti-LAG-3) or Sym023 (anti-TIM-3)","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Lag; Phase (matter); Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001279409,0.002221817,0.002208589,0.0006980827,0.0005226434,0.001242282,0.001137718,0.001602016,0.004977927],"category_scores_gemma":[0.0006211794,0.0006715917,0.001977779,0.0005315249,0.001319734,0.0009781134,0.0003610463,0.004847199,0.001660872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009502098,"about_ca_system_score_gemma":0.002064303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087107,"about_ca_topic_score_gemma":0.001984317,"domain_scores_codex":[0.9996699,0.0001216518,0.00001123639,0.00007160271,0.00002719568,0.00009842763],"domain_scores_gemma":[0.9993281,0.00009116642,0.00006656426,0.00006370825,0.00003936197,0.0004111041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.654626,0.1921985,0.001750929,0.0007304632,0.00128477,0.0002421435,0.000293188,0.004540095,0.06457617,0.0007366491,0.008852242,0.07016885],"study_design_scores_gemma":[0.3945534,0.5939497,0.001950361,0.00001849985,0.0002720839,0.000162421,0.00006016183,0.001155909,0.005120094,0.0002900259,0.00243413,0.00003314514],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877535,0.001861812,0.001152451,0.0009090507,0.0005482045,0.002327367,0.001730467,0.0002227582,0.003494342],"genre_scores_gemma":[0.9744093,0.002362883,0.003124338,0.001559899,0.0004127925,0.003737423,0.004398287,0.00007268939,0.009922229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004977927,"threshold_uncertainty_score":0.01665276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0580734026653386,"score_gpt":0.4154281216832031,"score_spread":0.3573547190178645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}