{"id":"W2977760151","doi":"10.7150/thno.35561","title":"FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer","year":2019,"lang":"en","type":"article","venue":"Theranostics","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Interactome; Breast cancer; Protein kinase B; Carcinogenesis; mTORC2; Cell growth; Cancer; Triple-negative breast cancer; Biology; Signal transduction; Chemistry; Cell biology; mTORC1; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001925827,0.0003191156,0.000211085,0.0006126451,0.0006003026,0.0006609528,0.0002841371,0.0004307741,0.008991902],"category_scores_gemma":[0.000215484,0.0002961044,0.0003298192,0.0004690333,0.0002815757,0.0003442014,0.000376161,0.0006142506,0.001502484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001273748,"about_ca_system_score_gemma":0.000671857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003990303,"about_ca_topic_score_gemma":0.005903167,"domain_scores_codex":[0.9998392,0.0000261058,0.000008323188,0.00002783622,0.00004341374,0.00005514752],"domain_scores_gemma":[0.9999436,0.000006531783,0.00001338444,0.000006438182,0.00001195504,0.00001816081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002469281,0.0001668858,0.004171438,0.0003808253,0.00009611583,0.0004719145,0.00008737203,0.001571516,0.9480818,0.00467194,0.006379193,0.03145179],"study_design_scores_gemma":[0.0002008862,0.0004287506,0.07460143,0.00005774322,0.0001700726,0.001665487,0.000266311,0.008647824,0.8479089,0.002059541,0.06395462,0.00003848718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671217,0.009847208,0.005220604,0.001834594,0.0003561894,0.00004090312,0.002233173,0.0003775873,0.01296819],"genre_scores_gemma":[0.9827822,0.002268909,0.001212562,0.0001741909,0.00003192994,0.00003471467,0.001641168,0.00003160933,0.01182274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008991902,"threshold_uncertainty_score":0.03008091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008987704075608303,"score_gpt":0.266860851188824,"score_spread":0.2578731471132157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}