{"id":"W2977760151","doi":"10.7150/thno.35561","title":"FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer","year":2019,"lang":"en","type":"article","venue":"Theranostics","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"PI3K/AKT/mTOR pathway; Cancer research; Interactome; Breast cancer; Protein kinase B; Carcinogenesis; mTORC2; Cell growth; Cancer; Triple-negative breast cancer; Biology; Signal transduction; Chemistry; Cell biology; mTORC1; Medicine; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002720199,0.0001175094,0.0001062946,0.00003688906,0.00004245057,0.00004412172,0.000148992,0.0001012182,0.000034177],"category_scores_gemma":[0.00004915764,0.00008738148,0.00001884436,0.00008728809,0.00002801555,0.000004627182,0.0001066989,0.0001455175,0.00001458677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000319494,"about_ca_system_score_gemma":0.0001173019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001662957,"about_ca_topic_score_gemma":0.0001022747,"domain_scores_codex":[0.9990641,0.0001124468,0.0001328805,0.0002533646,0.0001768654,0.0002602737],"domain_scores_gemma":[0.9995158,0.00004028296,0.00002719549,0.0002578883,0.0000835543,0.00007531133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002141186,0.00002992577,0.01248494,0.00002701727,0.00001292159,0.000001846334,0.0002791584,0.0008151383,0.9844368,0.00002690753,0.0000693239,0.001601901],"study_design_scores_gemma":[0.0006807658,0.0001827299,0.004799492,0.00003250774,0.000005081423,0.000006665088,0.0001195765,0.0003329003,0.9914988,0.00003765609,0.002152474,0.0001513715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970026,0.0002812457,0.0003654472,0.001276966,0.0000725131,0.0007850498,0.00002152881,0.00001529281,0.0001793476],"genre_scores_gemma":[0.9985694,0.0001290336,0.00006792422,0.0005609268,0.0001609537,0.00006381312,0.000007860208,0.00004523048,0.0003948068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007685445,"threshold_uncertainty_score":0.3563313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008987704075608303,"score_gpt":0.266860851188824,"score_spread":0.2578731471132157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}