{"id":"W2977815242","doi":"10.1038/s41467-019-12444-7","title":"Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; U.S. Department of Health and Human Services; BC Cancer Foundation; National Institutes of Health; Genome British Columbia; Genome Canada","keywords":"Epitope; Minigene; Cytotoxic T cell; Biology; Major histocompatibility complex; CD8; Antigen; T cell; Molecular biology; Computational biology; Cell biology; In vitro; Immune system; Genetics; Gene; Exon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002832433,0.0001223029,0.0001928448,0.0001368902,0.0003622986,0.00003240022,0.0004070434,0.0003806419,0.0006095228],"category_scores_gemma":[0.00009224987,0.0001182397,0.0000703249,0.0001975095,0.000144184,0.0003077401,0.0001778041,0.0006658905,0.0001558567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001915129,"about_ca_system_score_gemma":0.00006140602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004351402,"about_ca_topic_score_gemma":0.00002887081,"domain_scores_codex":[0.9989288,0.0003595554,0.0003339367,0.0001871425,0.00003952098,0.0001510659],"domain_scores_gemma":[0.9981821,0.0006803191,0.0002314622,0.0007737607,0.0001235949,0.000008819849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001858674,0.0001536896,0.008771425,0.00001150492,0.0001173346,2.614314e-8,0.0005736639,0.000002019817,0.9768512,0.009539641,0.001948032,0.001845592],"study_design_scores_gemma":[0.001327103,0.00009227118,0.1741082,0.00004180776,0.00006009961,0.000008802199,0.0006877102,0.00009202574,0.5399664,0.0005369805,0.2828723,0.0002062388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8623714,0.1335446,0.0004352954,0.0009873339,0.0007155814,0.0003137134,0.0001349542,0.00008531643,0.001411795],"genre_scores_gemma":[0.9922505,0.003787596,0.0003834984,0.0001268877,0.00001597035,0.00002000291,0.000658481,0.00001460026,0.00274249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4368848,"threshold_uncertainty_score":0.6673847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243669599313899,"score_gpt":0.2365748253778254,"score_spread":0.2241381293846864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}