{"id":"W2977815242","doi":"10.1038/s41467-019-12444-7","title":"Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Natural Sciences and Engineering Research Council of Canada; National Cancer Institute; U.S. Department of Health and Human Services; BC Cancer Foundation; National Institutes of Health; Genome British Columbia; Genome Canada","keywords":"Epitope; Minigene; Cytotoxic T cell; Biology; Major histocompatibility complex; CD8; Antigen; T cell; Molecular biology; Computational biology; Cell biology; In vitro; Immune system; Genetics; Gene; Exon","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601475,0.0004906948,0.0002496361,0.0004052727,0.000175325,0.0004902913,0.000261881,0.0002542225,0.0009734547],"category_scores_gemma":[0.000332622,0.0002320446,0.0001868331,0.0003336984,0.0001819045,0.0002638454,0.0004436685,0.0006216499,0.000799221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000156403,"about_ca_system_score_gemma":0.0001265952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007435848,"about_ca_topic_score_gemma":0.0002122196,"domain_scores_codex":[0.9997367,0.00006022215,0.00001929193,0.00005599004,0.00007862617,0.00004910934],"domain_scores_gemma":[0.9998215,0.00004997311,0.00003310969,0.00003227645,0.00002634855,0.00003679364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002549998,0.000008155781,0.00006116131,0.00000724055,0.000001470688,0.00001210565,0.000005208591,0.00007353292,0.998784,0.00003177785,0.00002044767,0.0009694338],"study_design_scores_gemma":[0.000008624759,0.0001121059,0.0006998589,0.000002083262,0.000007599095,0.0001026396,0.000008638894,0.001864408,0.9960814,0.00005994431,0.001049381,0.000003317666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9013979,0.0004315516,0.09502281,0.00008059344,0.00002935001,0.0002211313,0.001071646,0.0004570356,0.001288059],"genre_scores_gemma":[0.9177274,0.000554324,0.07475045,0.0001085367,0.00002342456,0.0003025291,0.00306997,0.0002200228,0.003243475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009734547,"threshold_uncertainty_score":0.003256559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243669599313899,"score_gpt":0.2365748253778254,"score_spread":0.2241381293846864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}