{"id":"W2977833465","doi":"10.1038/s41588-019-0504-x","title":"Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels","year":2019,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":430,"is_retracted":false,"has_abstract":false,"ca_institutions":"Medpharmgene (Canada); Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; British Heart Foundation; Albert-Ludwigs-Universität Freiburg; National Human Genome Research Institute; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; GlaxoSmithKline; Deutsche Forschungsgemeinschaft; Eunice Kennedy Shriver National Institute of Child Health and Human Development; European Regional Development Fund; European Commission; National Institute of General Medical Sciences; National Institute for Health and Care Research; American Heart Association; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Genome-wide association study; Expression quantitative trait loci; Genetics; Pleiotropy; Quantitative trait locus; Gene; Genetic association; Single-nucleotide polymorphism; Phenotype; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287856,0.0002297988,0.0002702044,0.0003995647,0.0001363799,0.0004483404,0.0001162657,0.0002123607,0.002882257],"category_scores_gemma":[0.0003130283,0.0001224973,0.0002899258,0.0004173766,0.0001407657,0.00007713889,0.000165758,0.0002143465,0.0003664234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407255,"about_ca_system_score_gemma":0.0001322773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001324222,"about_ca_topic_score_gemma":0.001150559,"domain_scores_codex":[0.9998752,0.00002763671,0.000007923188,0.00003942364,0.00002497307,0.0000248802],"domain_scores_gemma":[0.9997961,0.00009089365,0.00004525542,0.0000174113,0.00001577496,0.0000346237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00277401,0.00004899905,0.0984688,0.000185033,0.0003101378,0.001531621,0.0001966299,0.0004222196,0.87932,0.0008038771,0.0006966296,0.015242],"study_design_scores_gemma":[0.0001214345,0.0003530653,0.8434803,0.00005019685,0.0006039143,0.004933151,0.0003225895,0.002441349,0.1403763,0.00126135,0.006029565,0.00002673833],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98916,0.003299722,0.002783726,0.0002022085,0.0000378492,0.00001342721,0.002317738,0.0000878552,0.002097477],"genre_scores_gemma":[0.9953501,0.0008311936,0.001056834,0.00007198202,0.00002276149,0.00001329254,0.001013132,0.00003313303,0.001607498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002882257,"threshold_uncertainty_score":0.009642065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735640211162174,"score_gpt":0.2619559392345549,"score_spread":0.2445995371229332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}