{"id":"W2977833465","doi":"10.1038/s41588-019-0504-x","title":"Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels","year":2019,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":430,"is_retracted":false,"has_abstract":false,"ca_institutions":"Medpharmgene (Canada); Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; British Heart Foundation; Albert-Ludwigs-Universität Freiburg; National Human Genome Research Institute; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; GlaxoSmithKline; Deutsche Forschungsgemeinschaft; Eunice Kennedy Shriver National Institute of Child Health and Human Development; European Regional Development Fund; European Commission; National Institute of General Medical Sciences; National Institute for Health and Care Research; American Heart Association; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Genome-wide association study; Expression quantitative trait loci; Genetics; Pleiotropy; Quantitative trait locus; Gene; Genetic association; Single-nucleotide polymorphism; Phenotype; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002062313,0.000269052,0.000358719,0.0001145364,0.0001103309,0.00003846297,0.0001522113,0.0005952434,0.0004225832],"category_scores_gemma":[0.00002869655,0.0002443734,0.00006883025,0.000192131,0.00005776024,0.00008477058,0.00006053663,0.0007928706,0.00007728294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006830462,"about_ca_system_score_gemma":0.0001392285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001056929,"about_ca_topic_score_gemma":0.000004614871,"domain_scores_codex":[0.9983085,0.00004164943,0.0003099185,0.0004620403,0.0004943216,0.0003835763],"domain_scores_gemma":[0.9991103,0.00002463003,0.00008745216,0.0004320867,0.0001523493,0.0001931976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004118973,0.00008557153,0.1406504,0.0002417916,0.0001999268,0.00007490649,0.001370044,0.00009748887,0.8521065,0.001136306,0.0006591025,0.003336745],"study_design_scores_gemma":[0.002134982,0.0003449318,0.8959641,0.0001166679,0.0002325226,0.0003072241,0.0002067036,0.0004433284,0.04572649,0.0009985239,0.05309272,0.0004318447],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727995,0.02376932,0.0001248139,0.0003760326,0.000484387,0.000439418,0.0001414625,0.00008664461,0.001778456],"genre_scores_gemma":[0.9854986,0.0002717636,0.0108573,0.001412478,0.0004764407,0.000005756284,0.00008579747,0.00005490912,0.001336955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.80638,"threshold_uncertainty_score":0.9965256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735640211162174,"score_gpt":0.2619559392345549,"score_spread":0.2445995371229332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}