{"id":"W2977882995","doi":"10.1084/jem.20190789","title":"B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging","year":2019,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Rising Tide Foundation; Azrieli Foundation; Israel Science Foundation; Irma und Jacques Ber-Lehmsdorf - Stiftung; Gerald O. Mann Charitable Foundation; European Molecular Biology Organization","keywords":"Germinal center; B-cell receptor; Context (archaeology); B cell; Lymph; Fluorescence microscope; Affinity maturation; Molecular biology; breakpoint cluster region; Fluorescence; Cell; Cell biology; Cortex (anatomy); Chemistry; Biology; Antibody; Receptor; Pathology; Physics; Immunology; Genetics; Neuroscience; Optics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254072,0.0001687966,0.0001669236,0.0003194411,0.0001952835,0.0003240677,0.0002125164,0.0003570826,0.00104851],"category_scores_gemma":[0.00008530135,0.0001920293,0.0001331125,0.0001673846,0.000177592,0.0002609165,0.0002236826,0.0006075757,0.0003915415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002340323,"about_ca_system_score_gemma":0.00012899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006982999,"about_ca_topic_score_gemma":0.0009304513,"domain_scores_codex":[0.9999365,0.000008031584,0.00000244166,0.00001995133,0.00001230949,0.00002092575],"domain_scores_gemma":[0.9999155,0.00002153401,0.00002115552,0.000008182326,0.00001113594,0.00002265301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003371322,0.000005979477,0.0002652663,0.00001338621,0.000001414863,0.00002646694,0.00003124247,0.0000719435,0.9987167,0.00006446465,0.00001460793,0.0007548297],"study_design_scores_gemma":[0.00001460239,0.0001269768,0.02843647,0.00001129098,0.00001466047,0.0003987428,0.0001639592,0.006097258,0.9629551,0.0001638156,0.001604342,0.00001284304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804859,0.000894651,0.01596742,0.00005401625,0.00001010084,0.00002815009,0.0002627943,0.0001810551,0.002115922],"genre_scores_gemma":[0.9819726,0.0005360557,0.01502692,0.0000473305,0.000008955651,0.0000397451,0.0001972874,0.00005291769,0.002118156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104851,"threshold_uncertainty_score":0.003507614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004515939634301602,"score_gpt":0.2409952248585088,"score_spread":0.2364792852242072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}