{"id":"W2977918957","doi":"10.1093/brain/awz289","title":"Genetic and epigenetic study of an Alzheimer’s disease family with monozygotic triplets","year":2019,"lang":"en","type":"article","venue":"Brain","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baycrest Hospital; Western University; Occupational Cancer Research Centre; University of Toronto","funders":"Morris Kerzner Memorial Fund; Alzheimer Society; National Institute on Aging; National Institutes of Health; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Epigenetics; Alzheimer's disease; Disease; Genetics; Epigenesis; Neuroscience; Medicine; Biology; Psychology; DNA methylation; Gene; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002859064,0.0007153575,0.0005421658,0.002050759,0.00236839,0.0003384591,0.0003163374,0.0007104185,0.001914249],"category_scores_gemma":[0.001052662,0.000393061,0.0004628738,0.001049375,0.0006073655,0.0002152115,0.0005536138,0.0005005796,0.0002333576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006017545,"about_ca_system_score_gemma":0.0003697482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008259344,"about_ca_topic_score_gemma":0.00593353,"domain_scores_codex":[0.999599,0.00005052452,0.00004134666,0.00018333,0.00007658565,0.00004914216],"domain_scores_gemma":[0.9995821,0.00008408161,0.00008816182,0.00003645416,0.00005223964,0.000157009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001664457,0.00137721,0.5158694,0.0001169974,0.0002833617,0.3809595,0.007754455,0.0004258176,0.0677773,0.0007738937,0.0007691575,0.0222285],"study_design_scores_gemma":[0.00006282898,0.001265122,0.5880449,0.00003965198,0.0002064735,0.3986937,0.001298151,0.001169254,0.005876659,0.0004899499,0.002783155,0.00007015071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999096,0.0001078221,0.0002792718,0.0000518071,0.000009679869,0.00001481134,0.0000719737,0.000008687678,0.0003599028],"genre_scores_gemma":[0.9986142,0.000172995,0.0004087786,0.00005135177,0.00001932703,0.00000768598,0.00009575747,0.000006045736,0.0006239612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008259344,"threshold_uncertainty_score":0.01642257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339334092877788,"score_gpt":0.255565854317292,"score_spread":0.2421725133885141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}