{"id":"W2977918957","doi":"10.1093/brain/awz289","title":"Genetic and epigenetic study of an Alzheimer’s disease family with monozygotic triplets","year":2019,"lang":"en","type":"article","venue":"Brain","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baycrest Hospital; Western University; Occupational Cancer Research Centre; University of Toronto","funders":"Morris Kerzner Memorial Fund; Alzheimer Society; National Institute on Aging; National Institutes of Health; Consortium canadien en neurodégénérescence associée au vieillissement","keywords":"Epigenetics; Alzheimer's disease; Disease; Genetics; Epigenesis; Neuroscience; Medicine; Biology; Psychology; DNA methylation; Gene; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362212,0.0001472436,0.0001592331,0.00005051513,0.00003442638,0.00001726007,0.0001190306,0.00005743812,0.000008929827],"category_scores_gemma":[0.00002359586,0.0001286848,0.00002685622,0.00007705526,0.00004390654,0.00000362758,0.00005678527,0.00004146947,0.000003917647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002827466,"about_ca_system_score_gemma":0.00005516089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004617897,"about_ca_topic_score_gemma":0.0000626738,"domain_scores_codex":[0.9989732,0.0001185814,0.000199506,0.0003903809,0.0001534917,0.0001648747],"domain_scores_gemma":[0.9992191,0.00001854885,0.00008730219,0.0004701445,0.00005572413,0.000149153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005368452,0.0008066798,0.3301694,0.00004188078,0.0001707459,0.00001639529,0.0004034695,0.002941826,0.6424254,0.00002123349,0.00003896402,0.02242718],"study_design_scores_gemma":[0.001913544,0.003486952,0.9743602,0.00001092207,0.00009653129,0.000001775959,0.0003132308,0.0007200273,0.01792833,0.00009659582,0.0008235978,0.0002482689],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950764,0.003744457,0.0002747805,0.0000343361,0.00004688449,0.0006441868,0.000009486229,0.000006737883,0.000162688],"genre_scores_gemma":[0.9988639,0.00007507125,0.0007121668,0.00007798315,0.00005345455,0.0000206054,0.00002782942,0.00002832739,0.0001406744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6441908,"threshold_uncertainty_score":0.5247615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339334092877788,"score_gpt":0.255565854317292,"score_spread":0.2421725133885141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}