{"id":"W2977939617","doi":"10.1093/annonc/mdz265.002","title":"Implementation of PRO-CTCAE in phase I clinical trials identifies under reporting of adverse events","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Adverse effect; Clinical trial; Common Terminology Criteria for Adverse Events; Internal medicine; Tolerability; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.3132031,0.001019994,0.003442646,0.001819844,0.0008214391,0.00603454,0.002320163,0.002270535,0.002735896],"category_scores_gemma":[0.6239206,0.000854423,0.003863283,0.003526386,0.001973602,0.005179025,0.003434332,0.006490655,0.0004814071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001401624,"about_ca_system_score_gemma":0.005382729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007382523,"about_ca_topic_score_gemma":0.001212497,"domain_scores_codex":[0.5151611,0.41484,0.03350149,0.01460764,0.01923307,0.002656792],"domain_scores_gemma":[0.2365398,0.5913131,0.08938821,0.0608286,0.0192137,0.002716591],"domain_codex":null,"domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04432588,0.001186294,0.4441653,0.006454498,0.01882056,0.0001617166,0.002281107,0.01423051,0.002032659,0.01939725,0.01949296,0.4274512],"study_design_scores_gemma":[0.0151723,0.04262606,0.5661566,0.003491189,0.02478397,0.001590268,0.001485894,0.1620154,0.01431904,0.0913574,0.07647175,0.0005300621],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5034963,0.01800052,0.4227252,0.01956722,0.00258876,0.007345853,0.008438922,0.002177513,0.01565973],"genre_scores_gemma":[0.9291158,0.0007145595,0.06038349,0.003099746,0.0003674443,0.003111514,0.002173616,0.0002780642,0.00075557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6867969,"threshold_uncertainty_score":0.8469428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9240178606030828,"score_gpt":0.7853572982876386,"score_spread":0.1386605623154442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}