{"id":"W2978060560","doi":"10.1093/annonc/mdz242.077","title":"CONTESSA TRIO: A multinational, multicenter, phase II study of tesetaxel plus 3 different PD-(L)1 inhibitors in patients with metastatic triple negative breast cancer (TNBC) and tesetaxel monotherapy in elderly patients with her2- metastatic breast cancer (MBC)","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke","funders":"","keywords":"Medicine; Atezolizumab; Pembrolizumab; Internal medicine; Tolerability; Taxane; Oncology; Cohort; Triple-negative breast cancer; Metastatic breast cancer; Breast cancer; Nivolumab; Cancer; Adverse effect; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00143173,0.001344138,0.002043664,0.0005136514,0.0004747456,0.001195422,0.0009724795,0.001062044,0.004266425],"category_scores_gemma":[0.0007917571,0.0005293488,0.00169391,0.000512453,0.001028463,0.0009277853,0.0004246816,0.00358412,0.001167455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009124737,"about_ca_system_score_gemma":0.002007868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002292865,"about_ca_topic_score_gemma":0.006897077,"domain_scores_codex":[0.999687,0.0001308139,0.00001261349,0.00005806117,0.00002823303,0.00008325624],"domain_scores_gemma":[0.9993643,0.00008107481,0.0001048147,0.00005065816,0.00003407215,0.0003650662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7947903,0.06409783,0.009053745,0.000764065,0.002556469,0.000167809,0.0003736927,0.002895239,0.04112296,0.0005003187,0.007566422,0.07611118],"study_design_scores_gemma":[0.7220956,0.2530507,0.01546532,0.00004363254,0.001055986,0.0002323433,0.0001049361,0.00135597,0.002195147,0.0002550705,0.004090261,0.0000550912],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899189,0.002070861,0.0005244191,0.0008342262,0.000204557,0.001664986,0.0021841,0.0002050238,0.002392941],"genre_scores_gemma":[0.9785891,0.0029711,0.002424477,0.001651537,0.0003057999,0.002758743,0.005796068,0.0001018152,0.005401376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004266425,"threshold_uncertainty_score":0.01427257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03578482217766499,"score_gpt":0.3768492955626984,"score_spread":0.3410644733850334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}