{"id":"W2978067108","doi":"10.1101/788380","title":"The retinoblastoma tumor suppressor limits ribosomal readthrough during oncogene induced senescence","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Computer Research Institute of Montréal; Université de Montréal","funders":"Université de Montréal; Cancer Research Society; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Retinoblastoma; Biology; Suppressor; Carcinogenesis; Retinoblastoma protein; Ribosomal protein; Cancer; Cancer research; Translation (biology); Tumor suppressor gene; Senescence; Genetics; Cell biology; Gene; Cell cycle; Ribosome; RNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603917,0.000240812,0.0002345069,0.0002275503,0.0001131842,0.0003173103,0.000160966,0.0002037304,0.001539135],"category_scores_gemma":[0.0001169176,0.0000923098,0.0001482541,0.0001110419,0.0002077888,0.0001257608,0.0001627342,0.0003323729,0.0008501585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468697,"about_ca_system_score_gemma":0.0002628904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004214023,"about_ca_topic_score_gemma":0.0005066214,"domain_scores_codex":[0.9999207,0.00001717987,0.000005977096,0.00001386862,0.00001929007,0.00002296836],"domain_scores_gemma":[0.9999273,0.00001702705,0.00001830899,0.00001347621,0.000007884855,0.00001601662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001649055,0.00001750893,0.00008368817,0.00001657589,0.000001932261,0.00002572481,0.000006346439,0.00004513566,0.9980969,0.0002073804,0.00004849078,0.001285521],"study_design_scores_gemma":[0.00001872739,0.0001105456,0.0009869855,0.000003015141,0.00000373935,0.00009753384,0.000008765881,0.0004453958,0.9959384,0.00008773898,0.002297665,0.000001425518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863659,0.00409185,0.003574503,0.0002297848,0.00005429543,0.00002812252,0.0004225745,0.0002433295,0.004989638],"genre_scores_gemma":[0.9928949,0.0008990495,0.00134388,0.00003450467,0.00001415325,0.00001392596,0.0003707808,0.00004256161,0.004386037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539135,"threshold_uncertainty_score":0.005148947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536420386791943,"score_gpt":0.2313031492541271,"score_spread":0.2159389453862077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}