{"id":"W2978091090","doi":"","title":"Synthesis and characterization of the biological activity of the cisplatin analogs cis-PtCl2(dexrazoxane) and cis-PtCl2(levrazoxane) of the topoisomerase II inhibitors dexrazoxane (ICRF-187) and levrazoxane (ICRF-186).","year":2004,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Topoisomerase; Chemistry; Cisplatin; Pharmacology; Stereochemistry; Biochemistry; Enzyme; Biology; Cancer; Medicine; Internal medicine; Chemotherapy; Anthracycline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515353,0.000243138,0.0002581929,0.0001857916,0.0001583723,0.0001933599,0.0002202184,0.0001945329,0.001310331],"category_scores_gemma":[0.000218559,0.0001515867,0.0002080969,0.0002366463,0.0001198816,0.0001404506,0.00008870938,0.0002555075,0.0005355916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003513756,"about_ca_system_score_gemma":0.0004567561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001308112,"about_ca_topic_score_gemma":0.001516341,"domain_scores_codex":[0.9999055,0.00001459979,0.000009488203,0.0000218661,0.00003780276,0.00001068666],"domain_scores_gemma":[0.9998839,0.0000121974,0.00002237737,0.00001855786,0.00003482886,0.00002813081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009916569,0.00003456289,0.0001198243,0.00004766328,0.000007193012,0.00003892913,0.00001107968,0.0003482123,0.9962525,0.00007734352,0.00003982237,0.002923652],"study_design_scores_gemma":[0.00003308054,0.0004406976,0.001125577,0.000002667537,0.00001205795,0.00008639906,0.00000595851,0.0005936595,0.9940386,0.00001911287,0.003637026,0.000005218013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770476,0.004668281,0.01072358,0.000176699,0.00003461152,0.0003049806,0.002498656,0.00009065316,0.004454932],"genre_scores_gemma":[0.9763812,0.001466417,0.0123045,0.00006936723,0.0000128007,0.0001035717,0.00384597,0.00003696962,0.005779237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310331,"threshold_uncertainty_score":0.004383445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04383893967705684,"score_gpt":0.3139513286882184,"score_spread":0.2701123890111616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}