{"id":"W2978248451","doi":"10.14309/00000434-201610001-00663","title":"Efficacy and Safety of Dose Adjustment and Delayed Response to Ustekinumab in Moderate - Severe Crohnʼs Disease Patients: Results from the IM-UNITI Maintenance Study: 2016 ACG Presidential Poster Award","year":2016,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Clinical trial; Clinical endpoint; Placebo; Internal medicine; Maintenance therapy; Randomized controlled trial; Surrogate endpoint; Gastroenterology; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003309846,0.000651407,0.001962392,0.0001966214,0.0002663671,0.0007693615,0.0006334112,0.0009599005,0.002165572],"category_scores_gemma":[0.002427878,0.0003474167,0.001588475,0.0003287149,0.0005635991,0.0006548854,0.0004167201,0.002122926,0.0004035637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005208784,"about_ca_system_score_gemma":0.0007317062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004014571,"about_ca_topic_score_gemma":0.0006711732,"domain_scores_codex":[0.9988802,0.000677232,0.00009892558,0.0001223051,0.0001156555,0.0001056286],"domain_scores_gemma":[0.9974993,0.0006014826,0.0008162858,0.0002511937,0.0001276941,0.0007039488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9040282,0.009970005,0.02397911,0.0003724387,0.00137184,0.00004893344,0.0001240697,0.0003998963,0.00657696,0.00005533158,0.0009102907,0.05216276],"study_design_scores_gemma":[0.3017537,0.5483549,0.1440382,0.00007387278,0.001387662,0.0001744168,0.0000624665,0.0007440785,0.001694154,0.000122461,0.001549672,0.00004444119],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965339,0.001980148,0.0001017804,0.0002435293,0.00004527174,0.000262639,0.00030392,0.00001505554,0.0005138309],"genre_scores_gemma":[0.9976727,0.0005192962,0.0002707304,0.0002733142,0.0001677317,0.0002361354,0.0004540384,0.000005654108,0.0004004218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003309846,"threshold_uncertainty_score":0.01750433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005023276773427429,"score_gpt":0.2272994748812945,"score_spread":0.2222761981078671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}