{"id":"W2978265954","doi":"10.1021/acs.orglett.9b03172","title":"Synthesis of <i>trans</i> -2-Substituted Cyclopropylamines from α-Chloroaldehydes","year":2019,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; University of Toronto; Canada Foundation for Innovation","keywords":"Chemistry; Electrophile; Isomerization; Zinc; Amine gas treating; Halide; Ring (chemistry); Combinatorial chemistry; Medicinal chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00004970929,0.0002400433,0.000355599,0.0000592719,0.00003890715,0.00002271913,0.0003397633,0.0001358593,0.007671964],"category_scores_gemma":[0.00004350895,0.0002322313,0.0001305545,0.0001610039,0.00005823531,0.0001479404,0.00003455402,0.0001828958,0.0003929325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001069818,"about_ca_system_score_gemma":0.00003423448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001732766,"about_ca_topic_score_gemma":0.00001843756,"domain_scores_codex":[0.9986385,0.0000163239,0.0003322948,0.0004090592,0.0003349223,0.0002689698],"domain_scores_gemma":[0.9989063,0.0001741732,0.000173212,0.0006303061,0.00004418673,0.00007184116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003278825,0.00004000902,0.002083879,0.0001466811,0.00008197437,0.00001104264,0.0003491784,0.000006597247,0.99524,0.00002270758,0.0001354203,0.001849739],"study_design_scores_gemma":[0.0004355565,0.000005248557,0.0005054334,0.00009584705,0.00008386523,0.000009707035,0.0003075974,0.00001429342,0.9955956,0.0000280985,0.002655263,0.0002634462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964429,0.00009282033,0.0003247663,0.0006785879,0.0002999614,0.00009833946,0.00005267218,0.0001858535,0.001824108],"genre_scores_gemma":[0.9984559,0.00005309709,0.000828,0.0002576338,0.0001668421,0.0000138777,0.00004509746,0.00006775776,0.0001117773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007279031,"threshold_uncertainty_score":0.9932352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005319426326494881,"score_gpt":0.1824400210145799,"score_spread":0.177120594688085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}