{"id":"W2978307083","doi":"10.1016/j.bpj.2018.11.1691","title":"Timothy Syndrome-Associated Mutations Affect State-Dependent Contacts in L-Type Calcium Channel","year":2019,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Sodium channel; Cav1.2; Mutation; Calcium channel; Protein subunit; Chemistry; Voltage-dependent calcium channel; Domain (mathematical analysis); Crystallography; Biophysics; Calcium; Biology; Sodium; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274133,0.001405136,0.0004647955,0.0006295071,0.0006542397,0.0006532921,0.0007017058,0.002382297,0.004108411],"category_scores_gemma":[0.001969859,0.0001846717,0.0006517504,0.0004931432,0.001087015,0.0005969999,0.0006117054,0.0009815987,0.001221275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003950009,"about_ca_system_score_gemma":0.0003273271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002499,"about_ca_topic_score_gemma":0.001191254,"domain_scores_codex":[0.9995284,0.00009343186,0.0001067468,0.00008649082,0.000122397,0.00006251632],"domain_scores_gemma":[0.9982225,0.0007660088,0.0005977551,0.0001216187,0.00007277606,0.0002192359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001622212,0.0002108995,0.01103072,0.0002327429,0.0002066588,0.1304097,0.001376745,0.002147342,0.8286827,0.006657845,0.002029028,0.01539343],"study_design_scores_gemma":[0.0007375872,0.001426739,0.09166432,0.0003248931,0.0008741844,0.3206256,0.001279884,0.02663107,0.5242839,0.009758847,0.02195696,0.0004360385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891772,0.0004125936,0.004601798,0.0005089422,0.0002999911,0.00005299391,0.0005466347,0.0002064994,0.004193273],"genre_scores_gemma":[0.9977002,0.00009229267,0.0009905851,0.000138002,0.0000961979,0.00001729192,0.0001113544,0.00006238127,0.0007917753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004108411,"threshold_uncertainty_score":0.01374394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01331450933930693,"score_gpt":0.2741140137898611,"score_spread":0.2607995044505541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}