{"id":"W2978346381","doi":"10.14309/00000434-201610001-00710","title":"Genetic Polymorphisms Predict Response to Anti-TNF Treatment in Crohnʼs Disease","year":2016,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Single-nucleotide polymorphism; Genotype; Fas ligand; Internal medicine; Gastroenterology; Crohn's disease; Minor allele frequency; Tumor necrosis factor alpha; Odds ratio; SNP; Immunology; Allele frequency; Disease; Gene; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005293069,0.0002577667,0.0003249141,0.0004721939,0.000298148,0.0004242708,0.000194478,0.0004890735,0.002695348],"category_scores_gemma":[0.001867957,0.0001675236,0.0003166285,0.0006029052,0.0001984361,0.0001921908,0.0001905374,0.0004094414,0.0003540184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001263276,"about_ca_system_score_gemma":0.000142235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007703791,"about_ca_topic_score_gemma":0.0008696959,"domain_scores_codex":[0.9996848,0.0001090658,0.00005446451,0.0000695027,0.0000474348,0.00003472225],"domain_scores_gemma":[0.9984173,0.0005378098,0.0006751239,0.00006526434,0.00007944755,0.0002251015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003032115,0.00002258719,0.9980509,0.00001164567,0.00004358656,0.00008112555,0.00001844779,0.00004555929,0.000284386,0.000007276053,0.00005560496,0.001075667],"study_design_scores_gemma":[0.00002645159,0.0001728653,0.9982662,0.00001439598,0.00007251307,0.0006171854,0.00006638834,0.0003453322,0.0001488209,0.00003774967,0.0002291207,0.00000304633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991253,0.0004344337,0.00006087287,0.00004919594,0.000007032576,0.000003133916,0.0001307273,0.000003107287,0.0001861364],"genre_scores_gemma":[0.9995676,0.00007897476,0.0000975865,0.00001480135,0.00001060999,0.000002586474,0.0001186589,0.000001263565,0.0001080131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002695348,"threshold_uncertainty_score":0.009016871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004937783594210011,"score_gpt":0.22931624905272,"score_spread":0.22437846545851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}