{"id":"W2978398490","doi":"10.2196/13696","title":"VEROnA Protocol: A Pilot, Open-Label, Single-Arm, Phase 0, Window-of-Opportunity Study of Vandetanib-Eluting Radiopaque Embolic Beads (BTG-002814) in Patients With Resectable Liver Malignancies","year":2019,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Engineering and Physical Sciences Research Council; National Institute for Health and Care Research; University College London; British Heart Foundation; Cancer Research UK; BTG","keywords":"Medicine; Vandetanib; Tolerability; Hepatocellular carcinoma; Response Evaluation Criteria in Solid Tumors; Colorectal cancer; Phases of clinical research; Internal medicine; Radiology; Cancer; Clinical trial; Adverse effect; Sorafenib","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00528813,0.00308549,0.002876997,0.0006223711,0.0008966355,0.001856065,0.002811947,0.002996273,0.01892802],"category_scores_gemma":[0.002847029,0.001162029,0.001442657,0.0005356437,0.002015053,0.001635703,0.0009321931,0.0044029,0.003852854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001298466,"about_ca_system_score_gemma":0.005281858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007388513,"about_ca_topic_score_gemma":0.002235682,"domain_scores_codex":[0.9976368,0.001358323,0.0001117014,0.0003878946,0.0001981016,0.0003072278],"domain_scores_gemma":[0.9980567,0.0002952083,0.0003487405,0.0003282522,0.0002133854,0.0007577854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8493152,0.06602205,0.001506688,0.001273262,0.0004802267,0.000251163,0.0002750222,0.001614346,0.03642894,0.001336543,0.009327482,0.03216916],"study_design_scores_gemma":[0.6816266,0.2937684,0.003836193,0.0001084646,0.0002880321,0.0001749888,0.00007056324,0.001030413,0.003042103,0.0005546446,0.01544035,0.00005931093],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.5928254,0.002861829,0.01111132,0.001561278,0.001602066,0.3560127,0.009211684,0.00106049,0.02375315],"genre_scores_gemma":[0.5649674,0.002299047,0.02491674,0.00525296,0.0008773003,0.3636307,0.01381379,0.0002569724,0.02398504],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01892802,"threshold_uncertainty_score":0.06332052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4415402948607539,"score_gpt":0.4822965704156528,"score_spread":0.04075627555489886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}