{"id":"W2978478971","doi":"10.1021/acsinfecdis.9b00159","title":"Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane","year":2019,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Bacterial outer membrane; Polymyxin B; Polymyxin; Escherichia coli; Lipopolysaccharide; Colistin; Gram-negative bacteria; Cytoplasm; Biology; Bacteria; Colicin; Biophysics; Antibiotics; Membrane; Microbiology; Cell biology; Chemistry; Biochemistry; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000063825,0.0002894312,0.0001588787,0.0001257919,0.0001157917,0.0001201577,0.0001399248,0.0002502006,0.001857756],"category_scores_gemma":[0.00008845799,0.00008621143,0.0001839033,0.00007804827,0.0001881037,0.0001084184,0.0001729955,0.0005010164,0.0003353047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195425,"about_ca_system_score_gemma":0.0001672582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003758835,"about_ca_topic_score_gemma":0.0005160309,"domain_scores_codex":[0.9999114,0.00001705733,0.000006443963,0.00001432701,0.00002591153,0.00002482201],"domain_scores_gemma":[0.9999555,0.000007104496,0.0000102528,0.000005546951,0.000007627014,0.00001393741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007289687,0.00001810422,0.00004029977,0.00001763859,0.000001593396,0.0000221264,0.00000264169,0.00003717956,0.9990122,0.00003651087,0.00002278036,0.0007159687],"study_design_scores_gemma":[0.000007778923,0.0002130563,0.001793989,0.000002979517,0.000004226138,0.00009105082,0.000007724992,0.0002445819,0.9966979,0.00002349589,0.0009113192,0.000001883889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961195,0.0005602405,0.001111304,0.0001151201,0.00003466909,0.00001523442,0.0001554553,0.00003377362,0.001854705],"genre_scores_gemma":[0.995858,0.0003375626,0.001084456,0.00005873012,0.000007776772,0.00001401034,0.0003271894,0.000007038113,0.002305174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001857756,"threshold_uncertainty_score":0.006214797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003103974944573558,"score_gpt":0.2028642622476136,"score_spread":0.19976028730304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}