{"id":"W2978478971","doi":"10.1021/acsinfecdis.9b00159","title":"Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane","year":2019,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Bacterial outer membrane; Polymyxin B; Polymyxin; Escherichia coli; Lipopolysaccharide; Colistin; Gram-negative bacteria; Cytoplasm; Biology; Bacteria; Colicin; Biophysics; Antibiotics; Membrane; Microbiology; Cell biology; Chemistry; Biochemistry; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005596231,0.0001628049,0.000214222,0.00003476012,0.00004536589,0.00002060041,0.0001969558,0.0001498055,0.00004023866],"category_scores_gemma":[0.0001758882,0.000129582,0.0001325621,0.0001241962,0.0001385356,0.00001504002,0.00009194147,0.00005964392,0.000004175463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000243976,"about_ca_system_score_gemma":0.00007785461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001518008,"about_ca_topic_score_gemma":0.00005162699,"domain_scores_codex":[0.9989998,0.0001350663,0.0002987532,0.0002716013,0.0001508592,0.0001439627],"domain_scores_gemma":[0.9989168,0.00004630914,0.0003560068,0.0004783932,0.000159603,0.00004289257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005762971,0.0001141657,0.3188016,0.000037497,0.0001010807,2.524075e-7,0.00003019125,0.00003379897,0.6803451,0.00005538606,0.0002548764,0.0001684703],"study_design_scores_gemma":[0.0004154916,0.0001007332,0.3260216,0.00004996793,0.00006213613,7.344124e-7,0.00004670148,0.00002928677,0.672801,0.0001909955,0.0001557502,0.0001255899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977296,0.0001442081,0.000336556,0.00004962195,0.0003433636,0.0003038949,0.0006931506,0.00001278512,0.0003868119],"genre_scores_gemma":[0.9984115,0.000209932,0.00006263874,0.0001693294,0.00007286941,6.962331e-7,0.0008141653,0.00002242865,0.0002364644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007544021,"threshold_uncertainty_score":0.52842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003103974944573558,"score_gpt":0.2028642622476136,"score_spread":0.19976028730304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}