{"id":"W2978480841","doi":"10.1093/annonc/mdz246.006","title":"Impact of clonality and DNA repair mutations on plasma tumour mutation burden (pTMB) and immunotherapy efficacy in microsatellite stable (MSS) metastatic colorectal cancer (mCRC) in CCTG CO.26","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Queen's University; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Medicine; Colorectal cancer; Internal medicine; Oncology; Population; Microsatellite instability; Cancer; Gastroenterology; Cancer research; Gene; Microsatellite; Genetics; Biology; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002187627,0.0001403225,0.0002348555,0.0002688355,0.0003743758,0.0003417918,0.0001616264,0.0002634884,0.001975875],"category_scores_gemma":[0.0005728332,0.00009870124,0.0001657433,0.0003119471,0.0002194306,0.0001281574,0.0001633298,0.0003387274,0.0002418491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008675883,"about_ca_system_score_gemma":0.000576234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01828729,"about_ca_topic_score_gemma":0.03117672,"domain_scores_codex":[0.9998362,0.00003312025,0.000009647785,0.00003459512,0.00002247378,0.00006392887],"domain_scores_gemma":[0.9995117,0.00008213528,0.00008534807,0.00002139625,0.00003741465,0.000262043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0150761,0.0007733633,0.9298101,0.00005026996,0.00008486337,0.001325569,0.0004560179,0.0004350482,0.02946549,0.00008718378,0.001265342,0.02117069],"study_design_scores_gemma":[0.00008147383,0.003055601,0.9944141,0.000006246902,0.00005187799,0.0004272365,0.0001739115,0.0004565034,0.0008241446,0.00002533059,0.0004752361,0.000008320902],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994625,0.0001336261,0.0000126076,0.0000494036,0.000003480992,0.000003351624,0.00009270573,0.000004120925,0.000238224],"genre_scores_gemma":[0.9995376,0.00003266503,0.0000144188,0.00001918874,0.000003791333,0.000002713862,0.0001170086,0.000002149214,0.00027047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01828729,"threshold_uncertainty_score":0.03636169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02590654407178802,"score_gpt":0.3620657113871469,"score_spread":0.3361591673153589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}