{"id":"W2978530456","doi":"10.1093/annonc/mdz242.028","title":"Ribociclib (RIB) + letrozole (LET) in patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor-2–negative (HER2–) advanced breast cancer (ABC) and central nervous system (CNS) metastases: Subgroup analysis from the phase IIIb CompLEEment-1 trial","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Letrozole; Human Epidermal Growth Factor Receptor 2; Hormone receptor; Breast cancer; Oncology; Internal medicine; Cancer; Metastatic breast cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009314996,0.00117353,0.00211656,0.0004006686,0.0001884155,0.0007675619,0.0004273588,0.0006402871,0.002277258],"category_scores_gemma":[0.001072683,0.000335658,0.003190241,0.0005725692,0.0003341199,0.0005377918,0.0004075867,0.001545833,0.0003308037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006820181,"about_ca_system_score_gemma":0.0006692009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001743087,"about_ca_topic_score_gemma":0.008007713,"domain_scores_codex":[0.9996749,0.0001456157,0.0000270579,0.00006133005,0.00002628155,0.00006470983],"domain_scores_gemma":[0.9997318,0.00008249599,0.0000706276,0.00003326103,0.00001351848,0.00006827936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8929294,0.001125691,0.02231976,0.001533338,0.01760578,0.0001848305,0.0001075035,0.002639589,0.008059453,0.0002205765,0.003349877,0.04992422],"study_design_scores_gemma":[0.7381573,0.07764991,0.1138598,0.0003253689,0.05110623,0.0007068169,0.0003501489,0.004638448,0.002798808,0.001724837,0.008559883,0.0001225027],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811091,0.0143443,0.000340796,0.0005468644,0.0001931094,0.0003133369,0.00162421,0.00006104586,0.001467266],"genre_scores_gemma":[0.9914375,0.003716876,0.0003291574,0.0004538051,0.0001634883,0.0002182274,0.002327061,0.00001624675,0.001337722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002277258,"threshold_uncertainty_score":0.007618189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0271541311051166,"score_gpt":0.3359975925979312,"score_spread":0.3088434614928146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}