{"id":"W2978537230","doi":"10.1093/annonc/mdz252.011","title":"Inducible T cell costimulatory (ICOS) receptor agonist, GSK3359609 (GSK609) alone and in combination with pembrolizumab (pembro): Preliminary results from INDUCE-1 expansion cohorts (EC) in head and neck squamous cell carcinoma (HNSCC)","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Head and neck squamous-cell carcinoma; Agonist; Oncology; Head and neck; Internal medicine; Cancer research; Receptor; Cancer; Immunotherapy; Head and neck cancer; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004043213,0.0004217994,0.0005567722,0.0002432331,0.0002110178,0.0003833733,0.0002952551,0.0002585003,0.002071235],"category_scores_gemma":[0.0001859616,0.0001546328,0.0004733219,0.0002095803,0.0002836867,0.0002899849,0.000213201,0.001162792,0.0003966584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004296719,"about_ca_system_score_gemma":0.0005110925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433684,"about_ca_topic_score_gemma":0.005855973,"domain_scores_codex":[0.9998356,0.0000452274,0.000008107897,0.00002067977,0.0000253009,0.00006509019],"domain_scores_gemma":[0.9999044,0.00002189843,0.00001087132,0.00001340655,0.000007393528,0.00004199562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1159705,0.04188693,0.01404086,0.0008397822,0.0005221049,0.0004458478,0.0003993302,0.003539437,0.5516098,0.0002223591,0.005090223,0.2654329],"study_design_scores_gemma":[0.03679394,0.576703,0.1235385,0.00007533813,0.001305997,0.001159015,0.0004555378,0.004492797,0.245466,0.0002194137,0.0097383,0.00005213694],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972812,0.001112845,0.00009800917,0.00006553383,0.0000317734,0.0001320437,0.0002369804,0.00002765738,0.001013944],"genre_scores_gemma":[0.9961814,0.001104889,0.0004280632,0.00008349514,0.00002926115,0.0001205221,0.0007562169,0.000009957997,0.001286205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002071235,"threshold_uncertainty_score":0.00692898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431767128823211,"score_gpt":0.2983834981866705,"score_spread":0.2640658268984384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}