{"id":"W2978615859","doi":"10.1093/annonc/mdz260.112","title":"Safety, tolerability and activity of autologous T-cells with enhanced T-cell receptors specific to NY ESO 1/LAGE 1a (GSK3377794) alone, or in combination with pembrolizumab, in advanced non-small cell lung cancer: A phase Ib/IIa randomised pilot study","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Tolerability; Receptor; Cancer research; Immunology; Pharmacology; Immunotherapy; Internal medicine; Adverse effect; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001502562,0.001255906,0.00188744,0.0003994432,0.0002967983,0.0009687421,0.0007636008,0.001282888,0.002595191],"category_scores_gemma":[0.0008832171,0.0005686036,0.001705292,0.0003821575,0.001321997,0.001154977,0.0002564039,0.00278738,0.0007761247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008754456,"about_ca_system_score_gemma":0.0007585193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008297177,"about_ca_topic_score_gemma":0.001288644,"domain_scores_codex":[0.9993086,0.0003363172,0.00003422213,0.0001072274,0.00006393988,0.0001496924],"domain_scores_gemma":[0.9993724,0.0001782376,0.0001367789,0.00006139575,0.00003130899,0.0002198335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8909056,0.02769583,0.002421922,0.0004690081,0.001094407,0.0001128444,0.0001210214,0.001685787,0.03464222,0.0001599574,0.0008450258,0.0398463],"study_design_scores_gemma":[0.3313474,0.6536483,0.008205402,0.00002392051,0.0008640115,0.0001228296,0.00005892746,0.000850908,0.003849102,0.0001634171,0.0008387787,0.00002711326],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965221,0.001730418,0.0002325599,0.0001092853,0.0000689149,0.0003742253,0.0003163583,0.00002789224,0.0006182982],"genre_scores_gemma":[0.996837,0.0009138355,0.0002380804,0.0001445014,0.0001143878,0.0004405956,0.0004414473,0.00001138362,0.000858702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002595191,"threshold_uncertainty_score":0.008681774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03664897699676808,"score_gpt":0.3661601596427191,"score_spread":0.329511182645951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}