{"id":"W2978638108","doi":"10.1093/annonc/mdz249.007","title":"Primary renal tumour shrinkage in patients (pts) who did not undergo upfront cytoreductive nephrectomy (uCN): Subgroup analysis from the phase III JAVELIN Renal 101 trial of first-line avelumab + axitinib (A + Ax) vs sunitinib (S) for advanced renal cell carcinoma (aRCC)","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Foundation Medicine; EMD Serono; Genentech; EUSA Pharma; Ipsen; Incyte; Eisai; National Comprehensive Cancer Network; Alexion Pharmaceuticals; Sanofi; Exelixis; Genomic Health; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; American Society of Clinical Oncology; GlaxoSmithKline; Cilag; Astellas Pharma; Celldex Therapeutics; Pfizer","keywords":"Medicine; Axitinib; Subgroup analysis; Nephrectomy; Javelin; Urology; Renal cell carcinoma; Surgery; Internal medicine; Oncology; Kidney; Sunitinib; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009058158,0.0006043573,0.002041139,0.0003578289,0.0002445411,0.0007741126,0.0003649389,0.0005724339,0.001714794],"category_scores_gemma":[0.00111489,0.0002690284,0.005703757,0.0005008872,0.0002912165,0.0005006149,0.0004714033,0.001075216,0.0001865524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004450949,"about_ca_system_score_gemma":0.0004319324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001354716,"about_ca_topic_score_gemma":0.003399335,"domain_scores_codex":[0.9994172,0.0001558557,0.00007406623,0.0001749709,0.00007828699,0.00009964933],"domain_scores_gemma":[0.9995918,0.0001229274,0.0001172779,0.00007099903,0.00002243168,0.00007464708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4265337,0.0009568793,0.4427702,0.001545233,0.046274,0.0007404006,0.0002874399,0.003512267,0.0151572,0.0003050746,0.003411423,0.05850612],"study_design_scores_gemma":[0.02724882,0.01896058,0.9088986,0.000129844,0.03149061,0.001204125,0.0003960392,0.003302824,0.002206359,0.001006018,0.005056365,0.00009986085],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936426,0.004005009,0.000270409,0.0001282022,0.0001000118,0.00009257898,0.001005275,0.00001504919,0.0007408798],"genre_scores_gemma":[0.9974515,0.0004954253,0.0001100879,0.0001227991,0.00007654277,0.00006354411,0.001283778,0.000009207105,0.0003871844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041139,"threshold_uncertainty_score":0.005736589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04215692967529718,"score_gpt":0.3215684474265392,"score_spread":0.279411517751242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}