{"id":"W2978695194","doi":"10.1016/j.ctro.2019.09.006","title":"Intratumoral heterogeneity and hypoxia gene expression signatures: Is a single biopsy adequate?","year":2019,"lang":"en","type":"article","venue":"Clinical and Translational Radiation Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Princess Margaret Cancer Centre","funders":"Terry Fox Research Institute","keywords":"Hypoxia (environmental); Biopsy; Gene signature; Gene expression; Medicine; Gene; Pathology; Oncology; Biology; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002517744,0.0001363983,0.000242015,0.00003757756,0.00006759885,0.00001819817,0.00006613805,0.0003721496,0.00007673213],"category_scores_gemma":[0.00004041091,0.0001247628,0.00009370052,0.00005301649,0.0001640537,0.0000124786,0.0000286157,0.0001508061,0.00001148781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004822219,"about_ca_system_score_gemma":0.0001119481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004468192,"about_ca_topic_score_gemma":0.00001521562,"domain_scores_codex":[0.99878,0.000132355,0.0003612194,0.0004488965,0.0001062346,0.0001713223],"domain_scores_gemma":[0.9994408,0.0001007228,0.000109002,0.0001421782,0.00005735382,0.0001499482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001096702,0.0004825302,0.0908588,0.00003447294,0.0001539942,0.000003074964,0.0002333332,0.00007345449,0.7730059,0.0008683185,0.002958307,0.1302311],"study_design_scores_gemma":[0.005652111,0.001231046,0.4993525,0.00001467339,0.00008200921,0.00007184764,0.00003630003,0.0004466275,0.03993421,0.001150858,0.4515984,0.0004294027],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882,0.008390299,0.0007581055,0.0008198181,0.001147782,0.0002224479,0.00006805682,0.00001042667,0.0003830272],"genre_scores_gemma":[0.9942068,0.001290239,0.001639788,0.001113807,0.001300962,0.00001581131,0.0001989345,0.00001315299,0.0002204883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7330717,"threshold_uncertainty_score":0.508768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02597937290367396,"score_gpt":0.3279162729721365,"score_spread":0.3019369000684625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}