{"id":"W2978695194","doi":"10.1016/j.ctro.2019.09.006","title":"Intratumoral heterogeneity and hypoxia gene expression signatures: Is a single biopsy adequate?","year":2019,"lang":"en","type":"article","venue":"Clinical and Translational Radiation Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Princess Margaret Cancer Centre","funders":"Terry Fox Research Institute","keywords":"Hypoxia (environmental); Biopsy; Gene signature; Gene expression; Medicine; Gene; Pathology; Oncology; Biology; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0115031,0.000435827,0.001338114,0.0007035975,0.0004874782,0.0009012651,0.0005189293,0.001554685,0.0009243146],"category_scores_gemma":[0.01413307,0.0003796577,0.0003833287,0.00049651,0.001125439,0.001324919,0.0005953608,0.0005561668,0.000372371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003343012,"about_ca_system_score_gemma":0.0003816357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001247636,"about_ca_topic_score_gemma":0.003380161,"domain_scores_codex":[0.9954454,0.002231888,0.0004725006,0.0007091623,0.0009146839,0.0002263542],"domain_scores_gemma":[0.9883233,0.005375362,0.002521401,0.001480173,0.001677768,0.0006219741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003454264,0.000182488,0.7215475,0.0007357067,0.0007638767,0.001678022,0.0005725045,0.002645213,0.1681441,0.0004622161,0.001026187,0.09878785],"study_design_scores_gemma":[0.00006859881,0.002203575,0.9071028,0.0003053001,0.0006756225,0.01001501,0.001016316,0.01150266,0.06077538,0.001683609,0.004568455,0.00008269989],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562802,0.00713819,0.03347332,0.0008573834,0.0001631276,0.0001507619,0.0002162294,0.0001338985,0.001586945],"genre_scores_gemma":[0.9866998,0.000761175,0.01163656,0.0002677405,0.00008371726,0.00006846632,0.0001569205,0.00004071231,0.0002848925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0115031,"threshold_uncertainty_score":0.06083494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02597937290367396,"score_gpt":0.3279162729721365,"score_spread":0.3019369000684625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}