{"id":"W2978726884","doi":"10.1016/j.molcel.2019.09.012","title":"Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6","year":2019,"lang":"en","type":"article","venue":"Molecular Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; French Infrastructure for Integrated Structural Biology; National Institutes of Health; Agence Nationale de la Recherche","keywords":"CRISPR; Biology; Allosteric regulation; Cas9; DNA; Computational biology; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003079092,0.0004057712,0.0004504458,0.0002270196,0.0002961471,0.0008216586,0.0007773642,0.0005129757,0.004584397],"category_scores_gemma":[0.0003571214,0.0002507358,0.0003867589,0.0001770933,0.0005228479,0.000287189,0.0005107567,0.001279673,0.001760183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005441007,"about_ca_system_score_gemma":0.0003103855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000750393,"about_ca_topic_score_gemma":0.0009364813,"domain_scores_codex":[0.9994873,0.00005706779,0.0000461166,0.0001428438,0.0001762448,0.00009046576],"domain_scores_gemma":[0.9997904,0.0000368123,0.00005458945,0.00003971463,0.0000263655,0.00005220599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001624356,0.00002698866,0.00009525799,0.00004483798,0.000007864461,0.00004553987,0.000007992415,0.0001205651,0.9966545,0.0005268697,0.0002535373,0.002053649],"study_design_scores_gemma":[0.00001303898,0.00004348736,0.0003027132,0.000002896774,0.00000310278,0.00012432,0.000007377888,0.001455737,0.994949,0.00006451592,0.003027693,0.000006103193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9235672,0.003125351,0.04401776,0.00141331,0.0008023397,0.0001129845,0.001048337,0.00304464,0.02286793],"genre_scores_gemma":[0.98125,0.0005290223,0.009168904,0.0001971775,0.00002523571,0.0000247432,0.0003457377,0.0001618443,0.008297294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004584397,"threshold_uncertainty_score":0.01533633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002630197039431335,"score_gpt":0.2257106100944045,"score_spread":0.2230804130549731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}