{"id":"W2978726884","doi":"10.1016/j.molcel.2019.09.012","title":"Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6","year":2019,"lang":"en","type":"article","venue":"Molecular Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; French Infrastructure for Integrated Structural Biology; National Institutes of Health; Agence Nationale de la Recherche","keywords":"CRISPR; Biology; Allosteric regulation; Cas9; DNA; Computational biology; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009797978,0.0001598123,0.0001011481,0.00001948375,0.00004220795,0.00003295474,0.0001510851,0.0001077728,0.00004573296],"category_scores_gemma":[0.000009116102,0.0001319862,0.00008914481,0.00007880174,0.0000268197,0.000002344793,0.0001088847,0.0001015619,0.0001071739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008246936,"about_ca_system_score_gemma":0.00002415693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001345021,"about_ca_topic_score_gemma":0.000002445448,"domain_scores_codex":[0.9991291,0.00004251876,0.0001376577,0.0003033074,0.0001369664,0.0002504331],"domain_scores_gemma":[0.999431,0.000002961079,0.00003771377,0.0004427044,0.00003257743,0.00005300051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008117653,0.0000275968,0.0001001752,0.0000275807,0.00001372469,0.000008144118,0.00002389129,0.0002846334,0.9967846,0.0000142531,0.002288188,0.0004190464],"study_design_scores_gemma":[0.0003541958,0.0001243445,0.00008115103,0.000008780713,0.00001053572,0.00001383111,0.00003905736,0.0001112383,0.9392053,0.0000162302,0.05985586,0.0001794855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783864,0.001736967,0.01518831,0.0002364527,0.0001120654,0.0004478261,0.00001110642,0.00001651051,0.003864352],"genre_scores_gemma":[0.9965669,0.00003031119,0.0003188223,0.0004316943,0.00005163206,0.00003142149,0.0001128808,0.00003560963,0.002420747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05757936,"threshold_uncertainty_score":0.5382241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002630197039431335,"score_gpt":0.2257106100944045,"score_spread":0.2230804130549731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}