{"id":"W2978781448","doi":"10.1038/s41419-019-1987-1","title":"Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis","year":2019,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Burman University; Heart and Stroke Foundation; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Institute for Health and Care Research; Government of Canada; Thrasher Research Fund","keywords":"Wnt signaling pathway; Necrotizing enterocolitis; Regeneration (biology); Intestinal epithelium; Intestinal Disorder; Intestinal mucosa; Biology; Stem cell; Enterocolitis; Homeostasis; LGR5; Organoid; Cell biology; Medicine; Cancer research; Immunology; Internal medicine; Pathology; Epithelium; Signal transduction; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008191584,0.0001110873,0.0001445239,0.0001167064,0.0001191267,0.00003533448,0.00003553326,0.00003748674,0.00008558197],"category_scores_gemma":[0.00004330829,0.0001137332,0.00005310592,0.0000865516,0.00001334366,0.0001279633,0.00002308938,0.00006965089,0.00005065756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000581334,"about_ca_system_score_gemma":0.00004283657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005654457,"about_ca_topic_score_gemma":0.000006472648,"domain_scores_codex":[0.9991469,0.00004643845,0.0002244232,0.0002347192,0.0001221094,0.0002253467],"domain_scores_gemma":[0.9992804,0.00001903262,0.00007421336,0.0001205454,0.00007411724,0.0004316961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004387721,0.0003369568,0.3478532,0.002111212,0.000005480355,0.00003317226,0.0008037399,0.0001317501,0.6396213,0.001230367,0.001193137,0.002292061],"study_design_scores_gemma":[0.004762333,0.0009095313,0.5557481,0.0006665353,0.00006582508,0.00002984882,0.0002778546,0.002396832,0.4328088,0.00090015,0.0009653942,0.0004688019],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975941,0.0001841828,0.0002205578,0.0004955105,0.0003334023,0.0005041628,0.00002535855,0.00005563192,0.0005871205],"genre_scores_gemma":[0.9985343,0.00001012662,0.0002576968,0.0005289532,0.0001308099,0.00003827922,0.00005761933,0.00001504272,0.0004272166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2078949,"threshold_uncertainty_score":0.4637905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363882992490082,"score_gpt":0.2390865408931266,"score_spread":0.2254477109682258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}