{"id":"W2978781448","doi":"10.1038/s41419-019-1987-1","title":"Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis","year":2019,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Burman University; Heart and Stroke Foundation; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Institute for Health and Care Research; Government of Canada; Thrasher Research Fund","keywords":"Wnt signaling pathway; Necrotizing enterocolitis; Regeneration (biology); Intestinal epithelium; Intestinal Disorder; Intestinal mucosa; Biology; Stem cell; Enterocolitis; Homeostasis; LGR5; Organoid; Cell biology; Medicine; Cancer research; Immunology; Internal medicine; Pathology; Epithelium; Signal transduction; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599768,0.0003514505,0.0004281021,0.0004487844,0.0002041638,0.0002217244,0.0001978694,0.0004572697,0.001620561],"category_scores_gemma":[0.0002142903,0.0002072537,0.0003212353,0.0002316751,0.0003594134,0.0002125361,0.0002703709,0.0008640239,0.0002688889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000370548,"about_ca_system_score_gemma":0.0002249292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007225478,"about_ca_topic_score_gemma":0.0009072302,"domain_scores_codex":[0.9997779,0.00004399259,0.00003668871,0.00004792792,0.00003909182,0.00005438341],"domain_scores_gemma":[0.9998029,0.00002292506,0.00006148039,0.00001714745,0.00001101094,0.00008461683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008226543,0.0001411886,0.0008597942,0.0000669248,0.00001105908,0.0009509539,0.00005261401,0.00006114179,0.9948895,0.0001360009,0.00006149101,0.001946676],"study_design_scores_gemma":[0.0001258494,0.002507856,0.03991629,0.00005714059,0.00008176297,0.007005861,0.0003087722,0.001313642,0.9445786,0.0001918772,0.003891367,0.00002091142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971993,0.000949801,0.0008544725,0.00006599953,0.00002569915,0.00002410616,0.0002074381,0.00006563497,0.0006076014],"genre_scores_gemma":[0.9959161,0.0008883679,0.0007103742,0.00004128124,0.000005501184,0.00004451362,0.0003390791,0.00001906777,0.002035722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001620561,"threshold_uncertainty_score":0.00542134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363882992490082,"score_gpt":0.2390865408931266,"score_spread":0.2254477109682258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}