{"id":"W2978794082","doi":"10.5267/j.ccl.2019.9.001","title":"In vitro anti-BK polyomavirus activity of imidazo[1,2-c]pyrimidine and pyrimido[1,6 a]pyrimidine derivatives","year":2019,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Polyomavirus and related diseases","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Enamine; U.S. Department of Health and Human Services","keywords":"Chemistry; Pyrimidine; In vitro; Stereochemistry; Combinatorial chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001105322,0.000353139,0.0006710442,0.0001244119,0.00004166431,0.00001742167,0.0001494933,0.0001492639,0.0002776459],"category_scores_gemma":[0.00007530811,0.0003140212,0.0001705499,0.0003015948,0.0002884326,0.0001979204,0.000121625,0.0004776443,0.00001846181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009404184,"about_ca_system_score_gemma":0.00009620966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004695633,"about_ca_topic_score_gemma":1.676097e-7,"domain_scores_codex":[0.9982362,0.00003201601,0.0004024841,0.0005369268,0.0003325053,0.0004598257],"domain_scores_gemma":[0.9989365,0.00008451891,0.0002208629,0.0004478048,0.00004501311,0.0002652491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005457435,0.000521248,0.01680914,0.001057814,0.00007927832,0.0000412373,0.0001074483,0.00002528207,0.9773706,0.000004085126,0.0002109357,0.003227255],"study_design_scores_gemma":[0.002720833,0.00001430687,0.03074206,0.0003958282,0.0001234571,0.00004191828,0.0000458642,0.0004575504,0.9645508,0.000009775479,0.0005836062,0.0003139795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992483,0.004460261,0.000009149276,0.001964104,0.0002798683,0.0003424678,0.00006347051,0.00005346681,0.0003441794],"genre_scores_gemma":[0.99893,0.0005600755,0.00003648973,0.0001775152,0.0001559293,0.00001400091,0.00005333836,0.00003647008,0.00003617077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01393292,"threshold_uncertainty_score":0.9999312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257551093422508,"score_gpt":0.2709146020640069,"score_spread":0.2583390911297818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}