{"id":"W2978880457","doi":"10.1093/annonc/mdz394.065","title":"5-year survival outcomes of the CheckMate 067 phase III trial of nivolumab plus ipilimumab (NIVO+IPI) combination therapy in advanced melanoma","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ipilimumab; Medicine; Nivolumab; Oncology; Internal medicine; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001309669,0.0001580782,0.001168214,0.0002386363,0.00001959807,0.000002590132,0.0003100796,0.0002049424,0.001087541],"category_scores_gemma":[0.0002116639,0.0001146413,0.0002800408,0.0003702636,0.0002374364,0.00007461554,0.00008556482,0.0002747558,0.000009194555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064071,"about_ca_system_score_gemma":0.0005562297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003067626,"about_ca_topic_score_gemma":0.0001069314,"domain_scores_codex":[0.9977432,0.0004037629,0.0007649998,0.000240643,0.000537502,0.0003098646],"domain_scores_gemma":[0.9979792,0.0004938819,0.0004757368,0.0005882694,0.0004047792,0.00005819216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4136187,0.007728448,0.04494632,0.0002146191,0.0006308196,0.00001586148,0.002364138,0.00005529436,0.3552908,0.002245329,0.0002995237,0.1725901],"study_design_scores_gemma":[0.7016314,0.0393385,0.08258346,0.0001086961,0.00004141957,0.000007233672,0.0008860547,0.0003281866,0.1662637,0.0007125775,0.007895023,0.0002037137],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836113,0.0001459106,0.00000279641,0.002160909,0.0005625016,0.00179694,0.00001747395,0.00001093043,0.01169124],"genre_scores_gemma":[0.9956116,0.0006236002,0.00003511578,0.0001581488,0.00004330148,0.00003071032,0.00001395637,0.00002485208,0.003458727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2880127,"threshold_uncertainty_score":0.9998256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08452269851717625,"score_gpt":0.4290534193977082,"score_spread":0.344530720880532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}