{"id":"W2979041297","doi":"10.1016/j.cllc.2019.09.007","title":"Phase II Study Evaluating the Mechanisms of Resistance on Tumor Tissue and Liquid Biopsy in Patients With EGFR-mutated Non-pretreated Advanced Lung Cancer Receiving Osimertinib Until and Beyond Radiologic Progression: The MELROSE Trial","year":2019,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Servier; Les Laboratories Pierre Fabre; Takeda Pharmaceutical Company; AbbVie; Roche; Novartis; Meso Scale Diagnostics; Sanofi; Merck; GlaxoSmithKline; Boehringer Ingelheim; Amgen; Pfizer; Canadian Asian Studies Association; AstraZeneca; Bristol-Myers Squibb; Bayer","keywords":"Medicine; Osimertinib; Lung cancer; Liquid biopsy; Biopsy; Acquired resistance; Cancer; Pathology; Oncology; Cancer research; Internal medicine; Adenocarcinoma; ROS1","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009426523,0.0003002478,0.000734166,0.00006837536,0.0002635805,0.0000249509,0.000147067,0.0001001418,0.0001011414],"category_scores_gemma":[0.0003238723,0.0001469608,0.0000608445,0.0004424946,0.0002175031,0.0001048045,0.00009276499,0.0003952189,6.237962e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084462,"about_ca_system_score_gemma":0.0003530082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009013418,"about_ca_topic_score_gemma":0.000128908,"domain_scores_codex":[0.9973295,0.0003591137,0.000835137,0.0006880189,0.0004613508,0.0003268197],"domain_scores_gemma":[0.9978958,0.000667361,0.0005725688,0.0004923334,0.0002490234,0.0001228769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3896694,0.008160853,0.5350999,0.0004324331,0.002000804,0.000055355,0.006008149,0.0003140439,0.003216376,0.00004933157,0.0003571294,0.0546362],"study_design_scores_gemma":[0.4432709,0.1300872,0.4077735,0.00490355,0.004133906,0.000005079855,0.00178811,0.00481306,0.002329212,0.00007100473,0.00009661159,0.0007279441],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881952,0.002406257,0.00001046723,0.0008549528,0.0005273883,0.007762081,0.0000671251,0.00002975621,0.0001468087],"genre_scores_gemma":[0.9975258,0.0001543485,0.0002695898,0.0003754991,0.00009620873,0.001107955,0.00002643127,0.00003974331,0.0004044831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1273264,"threshold_uncertainty_score":0.5992889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02327523870040962,"score_gpt":0.4492838678513752,"score_spread":0.4260086291509656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}