{"id":"W2979084451","doi":"10.1371/journal.pone.0223245","title":"LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Island University","funders":"National Center for Advancing Translational Sciences; Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Institute of Biomedical Imaging and Bioengineering; National Space Biomedical Research Institute; Kenan Institute for Engineering, Technology and Science; National Aeronautics and Space Administration; Georgia Clinical and Translational Science Alliance; North Carolina Space Grant; National Institutes of Health; National Science Foundation","keywords":"Hydrostatic pressure; Cartilage; Wnt signaling pathway; In vivo; Cell biology; LRP5; Chemistry; Biomedical engineering; Hindlimb; Mechanotransduction; Chondrocyte; Biophysics; Biology; Anatomy; Medicine; Signal transduction; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001157617,0.0002306263,0.0002281016,0.0001859133,0.0001473413,0.0002577758,0.0001199647,0.0002223939,0.0008278835],"category_scores_gemma":[0.0001266153,0.0001545233,0.0003485541,0.0001269215,0.0002295137,0.0001491508,0.0001961793,0.0002397993,0.0001549874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001794191,"about_ca_system_score_gemma":0.0001294934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00107346,"about_ca_topic_score_gemma":0.001764199,"domain_scores_codex":[0.9998216,0.00002644603,0.00001698641,0.00003351788,0.00005482662,0.00004655774],"domain_scores_gemma":[0.9999236,0.000005277934,0.00003305111,0.000008137738,0.0000102008,0.00001966421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002115164,0.000009000251,0.0006348586,0.00003000541,0.000004704813,0.00004944896,0.00002539031,0.00003711356,0.9984862,0.00001057218,0.0000161394,0.0004849235],"study_design_scores_gemma":[0.00003556946,0.001292063,0.1756278,0.00001819563,0.00007060346,0.0005369694,0.0005008606,0.002390729,0.8177885,0.00007848612,0.001631802,0.00002838166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983584,0.0006668202,0.00052398,0.0000279833,0.00000897957,0.000008075592,0.0001341029,0.00001651778,0.0002552024],"genre_scores_gemma":[0.9977996,0.0003993273,0.0005630743,0.00002808433,0.000006032301,0.00003037231,0.0002438144,0.000004841495,0.0009247918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00107346,"threshold_uncertainty_score":0.00276953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008422366598067377,"score_gpt":0.1961549617722498,"score_spread":0.1877325951741824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}