{"id":"W2979140946","doi":"10.1039/c9nr02791b","title":"Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration","year":2019,"lang":"en","type":"article","venue":"Nanoscale","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":291,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"Hunan Provincial Innovation Foundation for Postgraduate; Chinese Academy of Medical Sciences; Fundamental Research Funds for Central Universities of the Central South University; China Postdoctoral Science Foundation; Central South University; Xiangya Hospital, Central South University; Natural Science Foundation of Hainan Province; National Natural Science Foundation of China","keywords":"Stromal cell; Microvesicles; Bone marrow; Regeneration (biology); Aptamer; Cancer research; Bone tissue; Cell biology; Medicine; Chemistry; Pathology; Biology; Molecular biology; Biochemistry; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001696775,0.0002647908,0.0002860461,0.00006274548,0.00008566659,0.00005211019,0.0001918613,0.0002496995,0.001041546],"category_scores_gemma":[0.00005904238,0.0002775112,0.0001725291,0.0001281845,0.00005198525,0.00001373911,0.0001707178,0.000118804,0.000582309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003880798,"about_ca_system_score_gemma":0.00009801234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003264828,"about_ca_topic_score_gemma":0.00002023693,"domain_scores_codex":[0.9981015,0.00009380293,0.0003584169,0.0007277705,0.0003474047,0.0003711251],"domain_scores_gemma":[0.998764,0.00001255848,0.0001294091,0.000736552,0.0001099509,0.000247512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003159324,0.0001893352,0.001051988,0.00001762587,0.0000433634,0.00002016427,0.00003142104,0.000169363,0.9822215,0.00004527576,0.01477747,0.001116496],"study_design_scores_gemma":[0.001103908,0.0002645558,0.00106346,0.00001897792,0.00003134874,0.00000895123,0.00002283293,0.0002174096,0.8490596,0.0002186502,0.1476638,0.0003265483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991418,0.002946711,0.002682433,0.0004806461,0.0007106935,0.0006151118,0.0002626778,0.00004666183,0.0008370444],"genre_scores_gemma":[0.954845,0.00004923402,0.0179423,0.0006038242,0.0006683758,0.00007004206,0.001249127,0.00006722602,0.02450492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.133162,"threshold_uncertainty_score":0.9999677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00588868000945608,"score_gpt":0.2177053644382161,"score_spread":0.2118166844287601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}