{"id":"W2979147097","doi":"10.1128/mbio.02148-19","title":"Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Ministry of Science and Technology, Taiwan","keywords":"Vacuole; Cell biology; Autophagy; Integrin; Chemistry; Stimulation; Biology; Receptor; Microbiology; Biochemistry; Apoptosis; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018402,0.000180549,0.0002271157,0.0001122285,0.0001219354,0.0002255901,0.00008672273,0.000217533,0.00103226],"category_scores_gemma":[0.00006241845,0.00006402592,0.0002209491,0.0001021747,0.0001099174,0.0001256685,0.0001326189,0.0003920087,0.0001663053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001818528,"about_ca_system_score_gemma":0.0001527347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004731836,"about_ca_topic_score_gemma":0.0007033361,"domain_scores_codex":[0.999886,0.00002746806,0.00001078181,0.00001280056,0.00001986548,0.00004300677],"domain_scores_gemma":[0.9999627,0.000004912505,0.000009492159,0.000005838431,0.000004285724,0.00001274279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001741004,0.00005116137,0.0002344418,0.00004318783,0.000006531334,0.00007991144,0.0000146072,0.00002578135,0.9982162,0.00009554339,0.00005636178,0.001002075],"study_design_scores_gemma":[0.00002375807,0.00064439,0.008919349,0.000007231607,0.00001813072,0.0002402983,0.00006523399,0.0008496334,0.9875473,0.00005884004,0.001622289,0.000003468169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960659,0.001222912,0.001202056,0.00007615675,0.00002621683,0.00001819811,0.0001176778,0.000051686,0.001219174],"genre_scores_gemma":[0.9979123,0.000361868,0.0004963978,0.00004666063,0.000006593944,0.00001800034,0.0001388127,0.000004348458,0.001014989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103226,"threshold_uncertainty_score":0.003453255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319353346793164,"score_gpt":0.2467355495170767,"score_spread":0.2335420160491451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}