{"id":"W2979147097","doi":"10.1128/mbio.02148-19","title":"Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Ministry of Science and Technology, Taiwan","keywords":"Vacuole; Cell biology; Autophagy; Integrin; Chemistry; Stimulation; Biology; Receptor; Microbiology; Biochemistry; Apoptosis; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281905,0.0002867851,0.0005320942,0.0002891195,0.00004065014,0.00004963855,0.00007116507,0.0002083014,0.0003314183],"category_scores_gemma":[0.00003090239,0.0002291281,0.00008433984,0.0002243884,0.00006297891,0.0001852317,0.00008682279,0.0003496272,0.0000701781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000173868,"about_ca_system_score_gemma":0.00003438004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001230136,"about_ca_topic_score_gemma":0.0005263748,"domain_scores_codex":[0.9985971,0.0001060368,0.00029046,0.0004933981,0.0001548006,0.0003582396],"domain_scores_gemma":[0.9993074,0.0001688746,0.0001137214,0.0002607295,0.00003422638,0.0001150319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002517503,0.0005127406,0.6852097,0.00007822848,0.00006355871,0.00009017732,0.0006858819,0.000002951941,0.3069274,0.00002246254,0.000005873301,0.006149331],"study_design_scores_gemma":[0.007022531,0.0007251952,0.5866722,0.0004334807,0.00002795463,0.00001601479,0.0004788626,0.00007090243,0.4039787,0.0001016468,0.0002445366,0.0002279509],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967853,0.00009005157,0.00000850769,0.00003413719,0.0006878959,0.001766371,0.00009142058,0.00004736197,0.0004889403],"genre_scores_gemma":[0.9992343,0.00002842398,0.00006026741,0.00004285633,0.0001370735,0.0002684687,0.00005053213,0.00003166151,0.0001464388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09853746,"threshold_uncertainty_score":0.9343572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319353346793164,"score_gpt":0.2467355495170767,"score_spread":0.2335420160491451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}