{"id":"W2979149584","doi":"10.1101/794198","title":"A Highly Conserved <i>Shh</i> Enhancer Coordinates Hypothalamic and Craniofacial Development","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Medical Research Council; Canadian Institutes of Health Research","keywords":"Enhancer; Sonic hedgehog; Diencephalon; Biology; Craniofacial; Cell biology; Gastrulation; Morphogenesis; Anatomy; Genetics; Embryogenesis; Gene expression; Neuroscience; Gene; Embryo; Central nervous system; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007456718,0.0003060857,0.0002011848,0.0002400173,0.0001345695,0.0002887669,0.0002374206,0.0002236747,0.001615764],"category_scores_gemma":[0.00006953033,0.0002513504,0.0002076375,0.00006418383,0.000302532,0.0001298086,0.0004395422,0.0005753184,0.000580938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524935,"about_ca_system_score_gemma":0.0001896248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006442785,"about_ca_topic_score_gemma":0.001232175,"domain_scores_codex":[0.9998646,0.00001152833,0.000008427378,0.00004689086,0.00003570506,0.00003276039],"domain_scores_gemma":[0.9998933,0.00001134064,0.00002876338,0.00001293306,0.00001113839,0.00004257792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001605685,0.000002777958,0.000102408,0.000004592142,0.000001215975,0.0000257796,0.000004337457,0.00002514325,0.999375,0.00008856377,0.00001253948,0.0003416464],"study_design_scores_gemma":[0.00001362642,0.00007958827,0.01413123,0.000008095211,0.000009308969,0.0005169157,0.00003122943,0.001325322,0.979611,0.00008527256,0.004181915,0.000006361705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788326,0.0005770979,0.01555027,0.00008082753,0.00004250068,0.0000323715,0.0006116495,0.0004000696,0.003872748],"genre_scores_gemma":[0.9837402,0.0001818937,0.006478332,0.00004818835,0.00001184518,0.00002709114,0.0008300813,0.000128476,0.008553836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001615764,"threshold_uncertainty_score":0.005405247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216199644741141,"score_gpt":0.2110124543944781,"score_spread":0.1988504579470667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}