{"id":"W2979187945","doi":"10.1016/j.celrep.2019.08.073","title":"A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Retinopathy of Prematurity Studies","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; Fonds de Recherche du Québec - Santé; Generalitat Valenciana; Ministerio de Educación, Cultura y Deporte; National Cancer Institute; National Institutes of Health; Human Frontier Science Program; Mountain Equipment Co-operative; Memorial Sloan-Kettering Cancer Center; Angiogenex; Breast Cancer Research Foundation","keywords":"Phenocopy; Neovascularization; Transcription factor; Cancer research; Retinal; Biology; Cell biology; Small molecule; Antagonist; In silico; Angiogenesis; Receptor; Genetics; Biochemistry; Phenotype; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031948,0.0002336884,0.0002421398,0.0001846683,0.0001212229,0.0001297132,0.0001701936,0.0002125219,0.002574371],"category_scores_gemma":[0.00007815901,0.00007515032,0.000126592,0.00009425117,0.0001041853,0.0001093365,0.00009214052,0.0004070103,0.0003318467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001348273,"about_ca_system_score_gemma":0.0001707199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003656378,"about_ca_topic_score_gemma":0.00124993,"domain_scores_codex":[0.9999608,0.000009113383,0.000003070789,0.000006065105,0.000007161047,0.00001376075],"domain_scores_gemma":[0.9999738,0.00000652268,0.000004817611,0.000002265544,0.000002587923,0.00001003259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001101341,0.0004511152,0.0006247737,0.0001871138,0.00004346111,0.0002094484,0.00002146874,0.0002383037,0.9699175,0.000357093,0.001169935,0.02567847],"study_design_scores_gemma":[0.0008999684,0.01418693,0.01487751,0.00003663415,0.0001235727,0.001443073,0.00006416299,0.00165184,0.9499114,0.0001592681,0.01662947,0.0000160542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842567,0.0070206,0.001447704,0.000280843,0.00007612173,0.0001350775,0.0006595255,0.0001718618,0.005951565],"genre_scores_gemma":[0.9893615,0.004026918,0.00138029,0.0001653952,0.00002414736,0.00007412999,0.001031425,0.00000898594,0.003927245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002574371,"threshold_uncertainty_score":0.008612156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290463234772725,"score_gpt":0.2261202666692437,"score_spread":0.2132156343215164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}