{"id":"W2979253142","doi":"10.1111/imm.13126","title":"Blockage of immune checkpoint molecules increases T‐cell priming potential of dendritic cell vaccine","year":2019,"lang":"en","type":"article","venue":"Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Tabriz University of Medical Sciences","keywords":"Priming (agriculture); Cancer immunotherapy; Dendritic cell; Immunotherapy; Gene silencing; T cell; Immune system; Antigen; Antigen presentation; Tumor microenvironment; Biology; Antigen-presenting cell; Cancer research; Cell biology; Cancer cell; Chemistry; Immunology; Cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007949384,0.0002303088,0.0002552037,0.0001280442,0.00006378734,0.0001795446,0.0001341887,0.0002579432,0.0008044396],"category_scores_gemma":[0.0001222341,0.00008743827,0.0001652754,0.00006614026,0.0001222224,0.0001740499,0.0000990381,0.0004457172,0.0001832858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817334,"about_ca_system_score_gemma":0.0001876601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001902322,"about_ca_topic_score_gemma":0.0001921009,"domain_scores_codex":[0.9999164,0.00001043556,0.000006645044,0.00001827433,0.00002189957,0.00002629254],"domain_scores_gemma":[0.9999508,0.00001426666,0.000009437733,0.00000504049,0.00001036378,0.00001010021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007179033,0.00004217504,0.00005386831,0.00003956469,0.000002771014,0.00001274626,0.000007230425,0.000130332,0.9976252,0.00006749464,0.00003208691,0.001914776],"study_design_scores_gemma":[0.00001727516,0.0003129804,0.0003310391,0.000002753168,0.00001097544,0.00002766329,0.000003163104,0.001300013,0.9968684,0.00002944908,0.0010946,0.000001728806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939113,0.00147995,0.00311691,0.00008268449,0.00004931002,0.00004561188,0.00005777242,0.00006366334,0.001192898],"genre_scores_gemma":[0.9966904,0.0006023763,0.001636764,0.00004645018,0.00001434472,0.0000337298,0.00008428675,0.00001169787,0.0008798927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008044396,"threshold_uncertainty_score":0.00269115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004116307584720238,"score_gpt":0.2020621442193833,"score_spread":0.1979458366346631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}