{"id":"W2979253142","doi":"10.1111/imm.13126","title":"Blockage of immune checkpoint molecules increases T‐cell priming potential of dendritic cell vaccine","year":2019,"lang":"en","type":"article","venue":"Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Tabriz University of Medical Sciences","keywords":"Priming (agriculture); Cancer immunotherapy; Dendritic cell; Immunotherapy; Gene silencing; T cell; Immune system; Antigen; Antigen presentation; Tumor microenvironment; Biology; Antigen-presenting cell; Cancer research; Cell biology; Cancer cell; Chemistry; Immunology; Cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003945086,0.000378498,0.001012813,0.0004018582,0.0001085844,0.000007837059,0.0006896658,0.0005154786,0.002439082],"category_scores_gemma":[0.00009661412,0.000360156,0.0004331607,0.0002436939,0.0003661225,0.0001253102,0.0003045895,0.0004784989,0.0005126362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000404719,"about_ca_system_score_gemma":0.0001717338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008230976,"about_ca_topic_score_gemma":0.000003669415,"domain_scores_codex":[0.9970695,0.0005863998,0.001231335,0.0004109391,0.00007077705,0.0006311008],"domain_scores_gemma":[0.9977673,0.0003542819,0.0007255374,0.0009329972,0.0002037307,0.00001620727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002396389,0.0008759308,0.0009353115,0.0001784614,0.0004561871,0.000010865,0.0003674605,0.00002447902,0.993143,0.0002147041,0.00004129644,0.001355907],"study_design_scores_gemma":[0.005435688,0.001279644,0.02066555,0.0001124637,0.0001273616,0.0001982552,0.0008183856,0.000006404928,0.9688691,0.00007230934,0.002094467,0.0003203196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9232791,0.07378222,0.0001658599,0.00005556344,0.0009294137,0.0004165989,0.00003723904,0.00005848095,0.001275545],"genre_scores_gemma":[0.9943705,0.00139686,0.000245889,0.00004022417,0.00001533087,0.0000184348,0.00009680164,0.00005337668,0.003762538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07238536,"threshold_uncertainty_score":0.999885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004116307584720238,"score_gpt":0.2020621442193833,"score_spread":0.1979458366346631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}