{"id":"W2979257942","doi":"10.1093/annonc/mdz394.080","title":"Pembrolizumab (pembro) + chemotherapy (chemo) in metastatic squamous NSCLC: Final analysis and progression after the next line of therapy (PFS2) in KEYNOTE-407","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston General Hospital","funders":"","keywords":"Medicine; Pembrolizumab; Oncology; Chemotherapy; First line therapy; Internal medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001842842,0.0005096268,0.000985159,0.0002631099,0.0003663525,0.0009094705,0.0005712999,0.0005151574,0.004634172],"category_scores_gemma":[0.001296089,0.0002840951,0.00172968,0.0004377254,0.0001821817,0.0008302215,0.0004921291,0.00172316,0.0007592703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008571804,"about_ca_system_score_gemma":0.001217291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001630796,"about_ca_topic_score_gemma":0.003623246,"domain_scores_codex":[0.9995601,0.000136081,0.00002227348,0.0001035576,0.00005520457,0.0001228744],"domain_scores_gemma":[0.9994803,0.0001661016,0.00007579535,0.00007307954,0.00005066916,0.0001541071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7179921,0.004211172,0.1478608,0.001034564,0.005637449,0.0003486414,0.000155915,0.00513801,0.01056824,0.0006408462,0.01486812,0.09154417],"study_design_scores_gemma":[0.1031694,0.1392905,0.6935708,0.0004202553,0.01380333,0.001377987,0.0004428368,0.008475529,0.009877835,0.00236125,0.02708797,0.000122342],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818871,0.003808013,0.0005792141,0.0003339038,0.0001246512,0.0002799642,0.009055967,0.00005107875,0.00388007],"genre_scores_gemma":[0.9823099,0.001283387,0.000742501,0.0002987431,0.0001513156,0.0002867373,0.01113159,0.00003681547,0.003759014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004634172,"threshold_uncertainty_score":0.01550287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07576311777996377,"score_gpt":0.3943962022662226,"score_spread":0.3186330844862588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}