{"id":"W2979276452","doi":"10.3390/v11100914","title":"Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists","year":2019,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Deutsche Krebshilfe; European Regional Development Fund; Deutsche Forschungsgemeinschaft; State Education Development Agency Republic of Latvia; Else Kröner-Fresenius-Stiftung; National Science Foundation","keywords":"Oncolytic virus; Measles virus; Immunotherapy; Immune system; T cell; Cancer research; Genetic enhancement; Biology; Virology; Fusion protein; Immunology; Virotherapy; Cancer immunotherapy; Viral vector; Gene; Vaccination; Measles; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448682,0.0002631691,0.0001698344,0.0002099193,0.00007658537,0.0002685346,0.0001000101,0.0002955756,0.0008077018],"category_scores_gemma":[0.0002719894,0.0001059975,0.0001549243,0.0001144059,0.0002319395,0.0002634726,0.00009840136,0.0005048894,0.0001982708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002416928,"about_ca_system_score_gemma":0.0001329415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003927323,"about_ca_topic_score_gemma":0.0004209005,"domain_scores_codex":[0.9997535,0.00005634677,0.00002537201,0.00003425684,0.00005501054,0.00007537342],"domain_scores_gemma":[0.9997961,0.00008529716,0.0000384865,0.00001353273,0.00002634896,0.00004030179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001376392,0.0000410074,0.0003002145,0.00001595883,0.000003114323,0.000006741284,0.00001318411,0.00009384887,0.9987419,0.00004105556,0.000006929515,0.0005985177],"study_design_scores_gemma":[0.00001024018,0.0006209211,0.002950043,0.000002984682,0.00001324218,0.00005354369,0.00001891737,0.0008043585,0.9952069,0.00002129088,0.0002952226,0.000002274608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977381,0.0008190139,0.0007213693,0.00002299829,0.000007489352,0.00001219731,0.00009583637,0.00001195316,0.0005709833],"genre_scores_gemma":[0.9986407,0.0002300202,0.0006212959,0.00001259793,0.000003237953,0.0000120072,0.0001044358,0.000005033848,0.000370711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008077018,"threshold_uncertainty_score":0.002702057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02892239456542743,"score_gpt":0.311455757147082,"score_spread":0.2825333625816545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}