{"id":"W2979293481","doi":"10.1182/blood.v122.21.1.1","title":"EZH2 and BCL6 Cooperate To Create The Germinal Center B-Cell Phenotype and Induce Lymphomas Through Formation and Repression Of Bivalent Chromatin Domains","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"PRC2; Bivalent chromatin; EZH2; Biology; Germinal center; Histone methyltransferase; Chromatin; H3K4me3; Cancer research; Histone H3; Molecular biology; Somatic hypermutation; Cell biology; B cell; Chromatin remodeling; Promoter; Genetics; Gene expression; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499896,0.0003700039,0.0001998131,0.0002799408,0.0001196658,0.0002648247,0.0002750949,0.0002860648,0.001918809],"category_scores_gemma":[0.00008226628,0.0001901651,0.0001996023,0.0001380516,0.0002643888,0.0001403138,0.0004289865,0.0005950394,0.0006091734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003124776,"about_ca_system_score_gemma":0.0001169864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003862486,"about_ca_topic_score_gemma":0.0008272514,"domain_scores_codex":[0.9997473,0.00003398673,0.00002094421,0.00005161888,0.0000852143,0.00006086908],"domain_scores_gemma":[0.999779,0.0000244741,0.00006156563,0.00002671227,0.00001044518,0.00009769404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004993023,0.00001431442,0.0001350958,0.000008678161,0.000003408102,0.00002457489,0.000004170107,0.00002285502,0.9993885,0.00006274066,0.00001858405,0.000267134],"study_design_scores_gemma":[0.00002155012,0.0001084665,0.002927799,0.000001368539,0.000008508574,0.0001648978,0.00001401862,0.000569856,0.9949729,0.0000306992,0.001177832,0.000001941783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944418,0.0004954264,0.00318313,0.00008094373,0.00001959244,0.00001573438,0.0003841693,0.0001640926,0.001215087],"genre_scores_gemma":[0.9950787,0.0001085842,0.001067801,0.00004709796,0.000005429072,0.00001966307,0.0003722129,0.0000395975,0.003260895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918809,"threshold_uncertainty_score":0.006419122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008531605639970961,"score_gpt":0.2299076134947921,"score_spread":0.2213760078548211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}