{"id":"W2979304829","doi":"10.1182/blood.v114.22.40.40","title":"GNF-2, An Allosteric BCR-ABL Inhibitor, Identifies a Novel Myristoylation-Mediated Mechanism Regulating the Ability of BCR-ABL to Activate HCK and IGF-1 Signaling.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Allosteric regulation; Kinase; Myristoylation; Dasatinib; Biology; Autophosphorylation; Cell biology; ABL; Imatinib mesylate; Proto-oncogene tyrosine-protein kinase Src; Protein kinase domain; Nilotinib; Signal transduction; Cancer research; Phosphorylation; Tyrosine kinase; Chemistry; Protein kinase A; Imatinib; Biochemistry; Mutant; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466539,0.0004267425,0.0002123424,0.0002054858,0.0001340901,0.000186493,0.0002855283,0.0004044215,0.001403356],"category_scores_gemma":[0.00009037592,0.000158691,0.0002630466,0.00008531265,0.0002565846,0.0002082847,0.0001903233,0.0004590928,0.0003057568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005662112,"about_ca_system_score_gemma":0.0001866177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004126923,"about_ca_topic_score_gemma":0.001044238,"domain_scores_codex":[0.9999238,0.000009451393,0.000002947567,0.0000156001,0.00002293636,0.00002527665],"domain_scores_gemma":[0.9999715,0.000005057689,0.00000858365,0.00000316795,0.000002418566,0.000009253282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009793085,0.00002245623,0.0001243434,0.00002708772,0.000003965288,0.00005423544,0.000003315255,0.00008932382,0.998004,0.0001465522,0.00006366571,0.001363135],"study_design_scores_gemma":[0.00009638358,0.0003886676,0.005843164,0.000005784415,0.00001052621,0.0009678088,0.000006538718,0.002093447,0.9868724,0.0001016724,0.003603687,0.000009923777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817949,0.004814636,0.006969783,0.0003249458,0.00007446568,0.0001646604,0.0004685399,0.0002794377,0.005108684],"genre_scores_gemma":[0.99168,0.001244759,0.004032657,0.0001326422,0.00001519327,0.00006473731,0.0005545856,0.00001483459,0.002260532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001403356,"threshold_uncertainty_score":0.0046947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710268104111163,"score_gpt":0.2610538417330227,"score_spread":0.243951160691911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}