{"id":"W2979352584","doi":"10.1182/blood.v122.21.3798.3798","title":"Targeting Folate Metabolism In Acute Myelogenous Leukemia","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"Gene knockdown; Chronic myelogenous leukemia; Biology; Cancer research; Leukemia; Mitochondrion; Cell culture; Molecular biology; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001330865,0.0002299154,0.000345775,0.000325569,0.0001399118,0.0003089307,0.0001727731,0.0002154867,0.001121651],"category_scores_gemma":[0.000145168,0.0001076473,0.0002280461,0.0003379254,0.0001137101,0.0001026268,0.000204704,0.0003743894,0.0003261773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003873179,"about_ca_system_score_gemma":0.000219184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006956951,"about_ca_topic_score_gemma":0.001522791,"domain_scores_codex":[0.9998807,0.00001229496,0.000007650029,0.00003176751,0.00004134281,0.0000262996],"domain_scores_gemma":[0.9999429,0.00001135846,0.00001850959,0.00000577572,0.00001049182,0.0000109683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003359221,0.00004099326,0.001839758,0.0003095613,0.00003946967,0.00007236648,0.00001749439,0.0004431672,0.9776947,0.0001435046,0.0006083414,0.01845469],"study_design_scores_gemma":[0.0001312101,0.0009165773,0.02668563,0.00006103547,0.0001749711,0.0007245159,0.0000565226,0.004038159,0.9165447,0.0004404258,0.05021061,0.00001562495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9475694,0.03544896,0.00824376,0.0006503018,0.000135513,0.0001024817,0.004418837,0.0006993921,0.002731381],"genre_scores_gemma":[0.9813871,0.007596357,0.005178292,0.0002911102,0.00002441798,0.00006739578,0.00337641,0.0000429949,0.002035931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121651,"threshold_uncertainty_score":0.003752232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004735059697007746,"score_gpt":0.2050087848665527,"score_spread":0.200273725169545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}