{"id":"W2979353094","doi":"10.1128/mbio.02343-19","title":"Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between<i>Plasmodium vivax</i>PvDBP and<i>Plasmodium falciparum</i>VAR2CSA","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Women and Children's Health Research Institute; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute; Fundación para el futuro de Colombia; Alberta Innovates; University of Alberta; Canadian Institutes of Health Research; Universidad de Antioquia; Mitacs; National Institutes of Health; Government of Canada","keywords":"Plasmodium falciparum; Biology; Plasmodium vivax; Heterologous; Epitope; Virology; Immunity; Malaria; Mechanism (biology); Plasmodium (life cycle); Computational biology; Antibody; Parasite hosting; Evolutionary biology; Genetics; Immune system; Immunology; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002202001,0.0002347438,0.0004200088,0.0001020232,0.000100536,0.00004568962,0.0003063523,0.0001300865,0.0004791943],"category_scores_gemma":[0.00002448793,0.000217002,0.00008214025,0.0001988978,0.0001873928,0.0002326984,0.0005202994,0.0002445349,0.0005109687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001245185,"about_ca_system_score_gemma":0.00001024102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003744147,"about_ca_topic_score_gemma":0.001333641,"domain_scores_codex":[0.9985226,0.0001073883,0.0003969047,0.0004152746,0.0001356717,0.0004221247],"domain_scores_gemma":[0.9992595,0.0001054482,0.000123176,0.0003896107,0.00001172606,0.0001105394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008870861,0.0001766035,0.039287,0.00003988814,0.00003255802,0.00001211406,0.00136813,0.00007232024,0.9573241,0.000269003,0.0002104264,0.001119137],"study_design_scores_gemma":[0.0008429736,0.0008555355,0.7137199,0.0001488629,0.00004793918,0.00003766294,0.0005678271,0.0001080176,0.2778018,0.002228647,0.003088577,0.0005522505],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973284,0.00004409554,0.0003124068,0.0004225855,0.0003351154,0.0003972886,0.00008585172,0.00003590688,0.001038371],"genre_scores_gemma":[0.9983356,0.00006029853,0.0009073323,0.0002497318,0.00001695011,0.00001539537,0.00002662819,0.0000200532,0.0003680027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6795223,"threshold_uncertainty_score":0.8849085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143876212973837,"score_gpt":0.2372624485005629,"score_spread":0.2258236863708245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}