{"id":"W2979353094","doi":"10.1128/mbio.02343-19","title":"Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between<i>Plasmodium vivax</i>PvDBP and<i>Plasmodium falciparum</i>VAR2CSA","year":2019,"lang":"en","type":"article","venue":"mBio","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Women and Children's Health Research Institute; Natural Sciences and Engineering Research Council of Canada; Children's Health Research Institute; Fundación para el futuro de Colombia; Alberta Innovates; University of Alberta; Canadian Institutes of Health Research; Universidad de Antioquia; Mitacs; National Institutes of Health; Government of Canada","keywords":"Plasmodium falciparum; Biology; Plasmodium vivax; Heterologous; Epitope; Virology; Immunity; Malaria; Mechanism (biology); Plasmodium (life cycle); Computational biology; Antibody; Parasite hosting; Evolutionary biology; Genetics; Immune system; Immunology; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001847601,0.0002717232,0.0001268001,0.0001159359,0.0001578951,0.000202744,0.0002754062,0.0003643231,0.001425775],"category_scores_gemma":[0.0001471124,0.0001053238,0.0001608722,0.0000414594,0.0003829664,0.0003414597,0.0003337026,0.0007605405,0.0002375583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001879384,"about_ca_system_score_gemma":0.000117239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001229721,"about_ca_topic_score_gemma":0.0001975475,"domain_scores_codex":[0.9999088,0.00001525363,0.000003456467,0.00002577355,0.00002052463,0.00002625989],"domain_scores_gemma":[0.9998791,0.00003094977,0.00003514648,0.00001971825,0.00001064527,0.00002442446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007372736,0.00002530844,0.000681317,0.00003456616,0.000004090879,0.00008488136,0.00003761752,0.0001071601,0.9958175,0.001270632,0.00003924419,0.001823991],"study_design_scores_gemma":[0.0000439098,0.001417389,0.01192228,0.00001962884,0.00003228148,0.001542489,0.0001644403,0.003542805,0.9734945,0.002125374,0.005682204,0.00001272654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977808,0.0006524618,0.0170558,0.0001954997,0.00004257694,0.00003412343,0.00004079835,0.00008011793,0.004090518],"genre_scores_gemma":[0.9970817,0.0001308552,0.00222649,0.00006628074,0.00001107519,0.000006018363,0.00002977881,0.000005425493,0.0004423497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001425775,"threshold_uncertainty_score":0.004769683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143876212973837,"score_gpt":0.2372624485005629,"score_spread":0.2258236863708245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}