{"id":"W2979390307","doi":"10.3390/v11100921","title":"Interferon γ and α Have Differential Effects on SAMHD1, a Potent Antiviral Protein, in Feline Lymphocytes","year":2019,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"SAMHD1; Biology; Phosphorylation; Molecular biology; Interferon; Virology; Viral replication; Reverse transcriptase; Cell culture; Nuclear protein; Cell biology; Transcription factor; RNA; Virus; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001056221,0.0002423483,0.0001872167,0.0001937304,0.0001305209,0.0002139021,0.00009604479,0.0002711277,0.001077901],"category_scores_gemma":[0.0001074484,0.00008369533,0.0002448444,0.0001078962,0.0001999067,0.0001398277,0.0001085188,0.0004062378,0.0001850727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261079,"about_ca_system_score_gemma":0.0000835812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004549896,"about_ca_topic_score_gemma":0.0006578101,"domain_scores_codex":[0.9998715,0.00002751118,0.00001474684,0.00002649471,0.00001897711,0.00004074393],"domain_scores_gemma":[0.9999284,0.00001977342,0.00001459425,0.00001016599,0.000009398765,0.00001777074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002679537,0.00001858226,0.0003452098,0.00002406607,0.00000265595,0.00004847595,0.00002317961,0.00002470277,0.9984655,0.00001474094,0.000009711596,0.0007552357],"study_design_scores_gemma":[0.00002415329,0.0009169989,0.01018491,0.000007886934,0.00002288853,0.0001849476,0.0001112684,0.0001906542,0.9869106,0.00003066592,0.001410677,0.000004276053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979242,0.0009578883,0.0002492875,0.00003528955,0.00001957902,0.00001253892,0.0001269467,0.00001057273,0.0006635282],"genre_scores_gemma":[0.9968207,0.0004819066,0.0004685177,0.00006363852,0.00001647967,0.00002704325,0.0002689355,0.000005093346,0.001847672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001077901,"threshold_uncertainty_score":0.003605902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233664579365607,"score_gpt":0.2583788660129793,"score_spread":0.2460422202193233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}