{"id":"W2979390307","doi":"10.3390/v11100921","title":"Interferon γ and α Have Differential Effects on SAMHD1, a Potent Antiviral Protein, in Feline Lymphocytes","year":2019,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"SAMHD1; Biology; Phosphorylation; Molecular biology; Interferon; Virology; Viral replication; Reverse transcriptase; Cell culture; Nuclear protein; Cell biology; Transcription factor; RNA; Virus; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005062717,0.0001506028,0.0002187703,0.0001232968,0.00004371245,0.00001858932,0.00007929982,0.0001038045,0.0001578747],"category_scores_gemma":[0.00003596233,0.0001078337,0.00003552692,0.00003983271,0.0000675955,0.00005589236,0.00008648947,0.0001467393,0.001930903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005921519,"about_ca_system_score_gemma":0.00002756261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000295839,"about_ca_topic_score_gemma":0.00009997705,"domain_scores_codex":[0.9991148,0.0001586874,0.0001263783,0.0002609028,0.00003555236,0.000303732],"domain_scores_gemma":[0.9996647,0.0001118217,0.00002947147,0.0001610069,0.00001227282,0.00002071702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001653619,0.0003757559,0.04958722,0.00005829646,0.0001145862,0.00003919541,0.0001510652,3.125688e-7,0.906851,0.0001271957,0.0002795064,0.04076222],"study_design_scores_gemma":[0.005364229,0.002267472,0.05695424,0.0002038384,0.00001066161,0.000008179846,0.00004405832,0.000005527715,0.9319218,0.00004655718,0.003027951,0.000145428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978051,0.0009020852,0.00000584881,0.00008083464,0.0001497902,0.0006289076,0.00003892889,0.00002922062,0.0003593316],"genre_scores_gemma":[0.9986748,0.0000657482,0.0000115943,0.000110259,0.00002201669,0.0000621648,0.00004872746,0.00001158527,0.0009931459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0406168,"threshold_uncertainty_score":0.9988462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233664579365607,"score_gpt":0.2583788660129793,"score_spread":0.2460422202193233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}