{"id":"W2979400106","doi":"10.14309/01.ajg.0000593520.44985.d3","title":"996 Disease Characteristics of Acute Hepatic Porphyria Patients: ENVISION, a Phase 3 Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial","year":2019,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta Hospital; Alberta Hospital Edmonton","funders":"","keywords":"Medicine; Internal medicine; Kidney disease; Placebo; Population; Chronic liver disease; Liver disease; Adverse effect; Multicenter trial; Randomized controlled trial; Gastroenterology; Surgery; Cirrhosis; Pathology; Multicenter study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008851399,0.000283944,0.001616212,0.00009334197,0.00004569108,0.00001932384,0.0005830349,0.00004814503,0.00004411504],"category_scores_gemma":[0.0002255329,0.000180657,0.0007350851,0.00009707965,0.0006074485,0.00001483067,0.0001394878,0.0001700577,0.000008586613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001623751,"about_ca_system_score_gemma":0.0001113978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001488235,"about_ca_topic_score_gemma":0.000002038721,"domain_scores_codex":[0.9969797,0.000874663,0.001196052,0.000251521,0.0003128307,0.0003852189],"domain_scores_gemma":[0.9963537,0.0000843708,0.002545938,0.000482932,0.0003090532,0.0002239332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9808203,0.001198557,0.01379702,0.000009743629,0.001260733,0.000007616381,0.00003815608,0.00002099112,0.002124612,0.00001386659,0.0001719931,0.0005364396],"study_design_scores_gemma":[0.9850253,0.01123241,0.002038402,0.00001946939,0.0011005,0.00002092257,0.00005586859,0.00009560237,0.0001154502,0.00004226066,0.0001431989,0.0001106031],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951781,0.000171402,0.001626727,0.0003685745,0.0008309069,0.001687568,0.0001079654,0.000003718334,0.00002505178],"genre_scores_gemma":[0.9978416,0.0005674705,0.0002236943,0.0009524477,0.0002445091,0.00004854522,0.00007225312,0.00002080926,0.000028694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01175862,"threshold_uncertainty_score":0.7366978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005157401253019397,"score_gpt":0.2663758276265353,"score_spread":0.2612184263735159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}