{"id":"W2979422744","doi":"10.1182/blood.v126.23.1863.1863","title":"Tracking Normal and Chronic Myeloid Leukemia Progenitor Cell Cycle Kinetics in a Defined Niche Using Live Time Lapse Confocal Imaging with Fucci2BL a Novel Lentiviral Bicistronic Reporter","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Biology; Progenitor cell; Stem cell; Cell biology; Cell cycle; Flow cytometry; Reporter gene; Cancer research; Cell; Immunology; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288414,0.0002718989,0.0001642053,0.0002882883,0.0001877321,0.0002845115,0.0002948382,0.0002897233,0.0007221093],"category_scores_gemma":[0.00009254451,0.0001534165,0.0001662577,0.0002411277,0.0002068538,0.0002033944,0.0001873306,0.0005064821,0.0002751435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000628077,"about_ca_system_score_gemma":0.0003219441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002306918,"about_ca_topic_score_gemma":0.002757385,"domain_scores_codex":[0.9998938,0.000008372947,0.000007428874,0.00004083696,0.0000272751,0.00002233406],"domain_scores_gemma":[0.9999071,0.00002013531,0.00002542887,0.00001099218,0.00002066917,0.00001567267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002792708,0.000008513089,0.0002035648,0.0000184567,0.000001089526,0.00001066766,0.00002078926,0.0001298266,0.998377,0.0001068017,0.0000309822,0.001064472],"study_design_scores_gemma":[0.000006028101,0.0000467974,0.002274625,0.000004631463,0.000003863765,0.00008785063,0.00002108091,0.006490079,0.9895822,0.00005373423,0.001423032,0.000006154802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9065599,0.0007922836,0.0881933,0.0001133291,0.00002332816,0.00009778988,0.001036678,0.000604219,0.002579049],"genre_scores_gemma":[0.8876035,0.0008860674,0.106259,0.0000768965,0.0000107104,0.0002910828,0.0007743028,0.0001201134,0.003978376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002306918,"threshold_uncertainty_score":0.004586995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01567107135828627,"score_gpt":0.2556956920971982,"score_spread":0.240024620738912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}