{"id":"W2979451218","doi":"10.1182/blood.v128.22.120.120","title":"Cereblon Splicing of Exon 10 Mediates IMiDs Resistance in Multiple Myeloma: Clinical Validation in the CoMMpass Trial","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Cereblon; Exon; Pomalidomide; Ubiquitin ligase; Alternative splicing; Molecular biology; HEK 293 cells; RNA splicing; Biology; Lenalidomide; Chemistry; Cell biology; Cell culture; Genetics; Ubiquitin; Multiple myeloma; Gene; Immunology; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007745653,0.00007153759,0.0001233697,0.00003478432,0.00001932783,0.000008038446,0.000160787,0.000119204,0.00001148953],"category_scores_gemma":[0.0007481277,0.00004470237,0.00005397093,0.00008354332,0.00006053289,0.000006418743,0.00003634935,0.00005880311,0.000003536075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000547204,"about_ca_system_score_gemma":0.0000341968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002228287,"about_ca_topic_score_gemma":0.0004746241,"domain_scores_codex":[0.9989719,0.0002416683,0.0003850715,0.0001777422,0.0001112392,0.0001123754],"domain_scores_gemma":[0.9994394,0.0001271874,0.000128755,0.0002519926,0.00003266502,0.00002002561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005607798,0.001300353,0.1052071,0.00003210747,0.00003211305,0.000004399172,0.0001806937,0.000001936946,0.8817889,0.0002215531,0.00215382,0.003469251],"study_design_scores_gemma":[0.03214734,0.00034209,0.02251009,0.00006599017,0.00001194928,8.512097e-7,0.00006864376,0.000004905141,0.940075,0.0001216539,0.004537841,0.0001135913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998407,0.0001395321,0.00008386443,0.0005342077,0.0000939454,0.0002807588,0.000007384949,0.000003824274,0.0004494967],"genre_scores_gemma":[0.999187,0.00009945566,0.0002455694,0.00004997812,0.0002257759,0.00003310005,0.00002974922,0.000006611845,0.0001227385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.082697,"threshold_uncertainty_score":0.182291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02941554972876177,"score_gpt":0.2918812347304499,"score_spread":0.2624656850016882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}