{"id":"W2979488028","doi":"10.1182/blood.v118.21.223.223","title":"The Growth Factor Independence 1 variant form GFI136N Predisposes to Acute Myeloid Leukemia by Inducing Epigenetic Changes in Oncogenes Such As Hoxa9","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Biology; Myeloid leukemia; Haematopoiesis; Syngenic; Myeloid; Epigenetics; Cancer research; Progenitor cell; Leukemia; Gene; Myelopoiesis; Phenotype; Ectopic expression; Stem cell; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009280786,0.0004926519,0.000228226,0.0004699261,0.0001465384,0.0002002214,0.0002015871,0.0002988988,0.005329121],"category_scores_gemma":[0.000119648,0.0001828868,0.0003293398,0.0001849459,0.000382383,0.00009017963,0.0003389181,0.0007825717,0.0004957382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002796033,"about_ca_system_score_gemma":0.0001973419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008325755,"about_ca_topic_score_gemma":0.001142433,"domain_scores_codex":[0.9998411,0.00002580948,0.00001626645,0.00004372774,0.00004264637,0.00003044019],"domain_scores_gemma":[0.9998453,0.00002167414,0.00006226423,0.0000158466,0.000004941793,0.00005011863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001334813,0.00002370267,0.0006521218,0.00001079186,0.000006646402,0.0001338188,0.00001033862,0.00005130579,0.9982653,0.00009493897,0.00003241795,0.0005851475],"study_design_scores_gemma":[0.0001146715,0.001417077,0.05614163,0.00002154545,0.00007788091,0.006824429,0.0001587292,0.002338138,0.9251006,0.0002700269,0.007509794,0.00002545859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975137,0.0001290688,0.0009724153,0.00007935521,0.00002236639,0.00002100752,0.0003725516,0.00005307428,0.0008363954],"genre_scores_gemma":[0.9963341,0.0001440647,0.0009330018,0.00003778877,0.000008639166,0.00001804627,0.0003872298,0.00002876842,0.002108309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005329121,"threshold_uncertainty_score":0.01782775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01108393879704784,"score_gpt":0.2280309401004942,"score_spread":0.2169470013034464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}